Related Products of 151049-87-5, These common heterocyclic compound, 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 3-bromo-1-methyl-pyrazole (156 mg) and 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)pyridazine (200 mg) in 1 ,4-dioxane (2 ml_) was added potassium phosphate (0.5 g) and water (0.4 ml_), followed by degassing and purging with nitrogen for 10 minutes. (0700) Chloro(crotyl)(tricyclohexylphosphine)palladium(ll) (28 mg) was added and the reaction mixture was degassed once again. This mixture was heated at 1 10C under microwave irradiation for 30 minutes. After cooling to room temperature the reaction mixture was concentrated and purified by preparative reverse phase HPLC to afford 4-(1-methylpyrazol-3-yl)pyridazine as a white solid. (0701) NMR (400MHz, CD3OD) 9.77 (dd, 1 H) 9.33 (dd, 1 H) 8.41 (dd, 11-1) 7.80 (d, 1 H) 7.10 (d, 11-1) 4.04 (s, 3H)
The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.