Tag: M.W:100-200

Application of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 5: 1 H-Pyrazol-4-amine. 4-Nitro-1H-pyrazole (Manchester organics; 1.13 g, 9.99 mmol) was dissolved in ethanol (50 ml). This solution was added carefully to 10% palladium on carbon (Aldrich; 102 mg) under a nitrogen atmosphere. The atmosphere was exchanged to hydrogen, and the mixture was stirred vigorously at room temperature under a hydrogen atmosphere. After 45 min, ca. 700 ml of hydrogen had been taken up, and no further hydrogen was taken up over the next 30 min. Stirring was stopped and the atmosphere was exchanged to nitrogen. The solution was filtered through cellite (10 g cartridge) and washed with further ethanol (150 ml). Relevant fractions (as verified by TLC) were combined and concentrated in vacuo to give a red oil. Trituration with DCM gave the title compound (815 mg) as a red solid; 1 H NMR (MeOH-d4, 400 MHz) delta (ppm) 7.20 (2 H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole, its application will become more common.

Related Products of 37687-18-6, A common heterocyclic compound, 37687-18-6, name is 1-(1-Methyl-1h-pyrazol-4-yl)-ethanone, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 282-Bromo- 1 -( 1 -methyl- 1 H-pyrazol-4-vDethanoneIn a 25 mL flask, 1 -(I -methyl- lH-pyrazol-4-yl)ethanone (0.602 g, 4.85 mmol) was dissolved in chloroform (20 mL). The colorless solution was made acidic with the addition of a few drops of HBr in acetic acid (3.92 mg, 0.05 mmol). A chloroform solution containing Br2 (0.262 mL, 5.09 mmol) was added dropwise via an addition funnel. The reaction mixture was stirred at room temperature for 1 h, and then concentrated under reduced pressure. The crude solid was triturated in ethyl acetate, filtered, and dried in vacuo. The free base was obtained by triturating the product in 5% NaHCCb for 2 h. The solid was collected by filtration, washed with water, isopropyl alcohol and then dried in vacuo. Isolation gave 874 mg of the title compound.LC/MS (ES+)[(M+H)+]: 204 for C6H7BrN2O.1H NMR (300 MHz, d6-DMSO): 3.88 (s, 3H), 4.56 (s, 2H), 7.99 (s, IH), 8.47 (s, IH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, A new synthetic method of this compound is introduced below., SDS of cas: 943541-20-6

A mixture of 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (494 mg, 2.5 mmol) in AcOH (20 mL) was stirred at 120 C for 4 h. The reaction mixture was concentrated under reduced pressure, and water was added to the concentrates. The generated solids was filtered and dried to afford 6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3(2H)-one (431 mg, 98 %). 6-(1-Methyl-1H-pyrazol-4-yl)pyridazin-3(2H)-one (2a) 1HNMR (300 MHz, CDCl3) delta 8.70 (d, J = 11.3 Hz, 1H), 7.96(s, 1H), 6.94 (s, 1H), 6.62 (d, J = 11.3 Hz, 1H), 3.95 (s, 3H).

The synthetic route of 943541-20-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 51985-95-6

c) l-Methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-lH-pyrazole-3-carboxylic acid methyl esterTo a stirred solution of 5 -hydroxy- 1 -methyl- lH-pyrazole-3-carboxylic acid methyl ester (400 mg, 2.6 mmol) and (5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-methanol (500 mg, 2.6 mmol) inTHF(10 mL) at 5 0C under argon was added triphenylphosphine (862 mg, 3.3 mmol), then diethyl azodicarboxylate (573 mg, 3.3 mmol) was added dropwise. The reaction mixture was warmed to room temperature and stirred overnight. The reaction mixture was then evaporated. Purification by chromatography (silica, dichloromethane: methanol = 9:1) then purification using a 5 x 50 cm Chiralpak AD column at room temperature using an isopropanol:heptane (2:8) mobile phase with UV detection at 220 nM afforded the title compound (400 mg, 48percent) as a white solid. MS: m/e = 328.3 [M+H]+.

According to the analysis of related databases, 51985-95-6, the application of this compound in the production field has become more and more popular.

Reference of 26621-44-3, A common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 3-nitro-1H-pyrazole (5 g, 44.22 mmol, 1 eq) in DMF (50 mL) was added NaH (2.12 g, 53.06 mmol, 60 wt.% in mineral oil, 1.2 eq) at 0 C. The reaction mixture was stirred at 0 C for 0.5 hour. Then 2,2-dimethyloxirane (3.51 g, 48.64 mmol, 1.1 eq) was added into the above mixture at 0 C. The resulting mixture was warmed to 25 C and stirred at 25 C for 1 hour. The reaction mixture was quenched by addition of H2O (100 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with brine (2 x 30 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give the title compound (3.7 g, crude) as yellow oil, which was used directly in the next step.1H NMR (400 MHz, CDCl3): d 7.60 (dd, 1 H), 6.93 (d, 1 H), 4.21 (s, 2 H) and 1.27 (s, 6 H). One exchangable proton not observed.LCMS: m/z 208.1 (M+Na)+(ES+)

The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 578008-32-9 as follows. Quality Control of tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate

A mixture of tert-butyl ((1R,3s,55)-3-((7-chloro- 1 ,6-naphthyridin-5-yl)amino)-8- azabicyclo[3.2.ljoctane-8-carboxylate (30 g, 77 mmol), tert-butyl 3-amino-5-methyl-1H- pyrazole-1-carboxylate (19.78 g, 100 mmol), Cs2CO3 (50.3 g, 154 mmol), PdXPhos(1.517 g, 1.93 mmol) and XPhos (0.919 g, 1.93 mmol) was degassed with nitrogen 3 times, and then 1,4-dioxane (300 mL) was added. The reaction mixture was degassed with nitrogen 5 times, heated to reflux, stirred for 16 h, and cooled to 75 C. Water (90 mL) was added and the reaction mixture was heated to reflux and stirred at reflux for48 h. Water (210 mL) was added slowly and the reaction mixture was stirred at RT fort 1 h, and filtered. The filter cake was washed with 1:1 dioxane:water (50 mL) and dried at 50 C under vacuum overnight to give crude title intermediate (35.34 g).The crude product was dissolved in DMF (173 mL). SiliaMetS thiol functionalized silica (8.65 g) was added and the reaction mixture was stirred for 45 mm at80 C, cooled to RT, filtered, and rinsed with DMF (35 mL). To the filtrate was added water (346 mL) dropwise and seeds from a previous preparation by the same procedure. The reaction mixture stirred at RT for 6 h, filtered, washed with water (35 mL) and dried at 50 C under vacuum to give the title intermediate (33.6 g, 97 % yield). HPLC Method 3 Retention time 16.89 mm

According to the analysis of related databases, 578008-32-9, the application of this compound in the production field has become more and more popular.

Related Products of 63680-90-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63680-90-0, name is 3-Chloro-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

10022] A 100 mE, 3-neck flask was charged with 3-chloro-1H-pyrazol-4-amine hydrochloride (5.00 g, 32.5 mmol), tetrahydrofuran (25 mE) and water (25 mE). The resulting suspension was cooled to 5C. and sodium bicarbonate (10.9 g, 130 mmol) was added, followed by dropwise addition of3-((3,3,3,-trifluoropropyl)thio)propanoyl chloride (7.52 g,34.1 mmol) at <5 C. The reaction was stirred at <10 C. for1 hour, at which point thin layer chromatography analysis (Eluent: 1:1 ethyl acetate/hexane) indicated the starting material was consumed and the desired product was formed. The reaction mixture was diluted with ethyl acetate (25 mE) and water (25 mE). The layers were separated and the aqueous layer was extracted with ethyl acetate (3x25 mE). The organic layers were combined and concentrated to dryness. The residue was suspended in 2:1 methyl tert-butylether/heptanes (30 mE), stirred for 1 hour and filtered. The solid was rinsed with 2:1 methyl tert-butylether/heptanes (20 mE) and further dried under vacuum at room temperature (about 22 C.) to afford a white solid (7.80 g, 80%): mp 83-85 C.; ?H NMR (400 MHz, DMSO-d5) oe 12.90 (s, 1H), 9.59 (s, 1H), 8.02 (s, 1H), 2.82 (t, J=7.2 Hz, 2H), 2.76-2.69 (m, 2H), 2.66 (t, J=7.1 Hz, 2H), 2.62-2.48 (m, 2H); ?3C NMR (101 MHz, DMSO-d5) oe 168.97, 129.95, 126.60 (q, J=277.4 Hz), 123.42, 116.60, 35.23,33.45 (q, J=27.3 Hz), 26.85, 23.03 (q, J=3.4 Hz); ElMS mlz301 ([M]j. The chemical industry reduces the impact on the environment during synthesis 3-Chloro-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Application of 5071-61-4, These common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

Statistics shows that 5-Phenyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5071-61-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89179-62-4, name is 1-Methyl-1H-pyrazole-3-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-pyrazole-3-carboxamide

Description 30; (1-Methvl-pvrazole-3-methanamine) A solution of Description 29 (0.08g) in anhydrous tetrahydrofuran (5ml) was treated with a 1 M solution of borane/tetrahydrofuran complex in tetrahydrofuran (3. 5mi) and the mixture was heated at 65¡ãC for 18hrs. On cooling the mixture was cautiously quenched by dropwise addition of methanol followed by 2N hydrochloric acid. The solvents were removed by evaporation, and the residue was made basic with triethylamine and concentrated in vacuo. The mixture was dissolved in a small volume of methanol applied onto a sulphonic acid SCX ion exchange cartridge (10g), eluting with methanol followed by 10percent 0. 880 ammonia in methanol. The basic fraction was evaporated in vacuo to give the title compound (0.054g) as a colourless oil which also contained-10percent of 1 H- pyrazole-3-methanamine [CAS No. 37599-58-9]. 1H nmr (D4MeOH), No. 3. 84 (2H, s, CH2) ; 3. 86 (3H, s, Me); 6.28 (1H , m, Ar); 7.53 (1H, m, Ar).

According to the analysis of related databases, 89179-62-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 17635-45-9, These common heterocyclic compound, 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 11-a (79 mg, 0.50 mmol) and compound 5 (70 mg, 0.17 mmol) were dissolved in n-butanol (2 mL), p-toluene sulfonic acid monohydrate (95 mg, 0.50 mmol) was added. The mixture was heated to 110¡ã C. and stirred for 16 hours. After cooled to room temperature, the mixture was stirred for further 30 minutes, and there was solid precipitated. After filtration, the solid was purified by preparation HPLC (mobile phase:acetonitrile, water (0.05percent trifluoroacetic acid); gradient: 60percent-90percent-10percent) to give yellow solid T-11 (31 mg, yield: 34percent). LC-MS (ESI): m/z=546 [M+H]+. (0169) 1H-NMR (400 MHz, CDCl3) delta: 8.49 (s, 1H), 8.40 (s, 1H), 7.94 (d, J=6 Hz, 1H), 7.91 (d, J=2 Hz, 1H), 7.84 (d, J=9 Hz, 2H), 7.687.73 (m, 3H), 7.40 (d, J=6 Hz, 2H), 6.47 (t, J=2 Hz, 1H), 4.65 (d, J=9 Hz, 2H), 4.26 (d, J=9 Hz, 2H), 3.43 (s, 2H), 3.10 (q, J=6 Hz, 2H), 1.43 (t, J=6 Hz, 3H) ppm

Statistics shows that 4-Pyrazol-1-yl-phenylamine is playing an increasingly important role. we look forward to future research findings about 17635-45-9.