Category: 5071-61-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 5071-61-4

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5071-61-4.

Reference:
Article; Doma, Anuradha; Kulkarni, Ravindra; Palakodety, Radhakrishna; Sastry, G. Narahari; Sridhara, Janardhan; Garlapati, Achaiah; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 6209 – 6219;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 5071-61-4, These common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2A: Synthesis of N-{4-[(4,6-dimethylpyrimidin-2-yl)({[2- (trimethylsilyl)ethoxy] methyl}) sulfamoyl]phenyl}-3-phenyl-lH-pyrazole-5-carboxamide, 10.2 [00292] HATU (294mg, 0.77 mmol) and DIPEA (0.27 ml, 1.55 mmol) were added at rt to a stirred solution of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-N-{[2- (trimethylsilyl)ethoxy]methyl}benzene-l-sulfonamide (10.1, 211 mg, 0.52 mmol) in DMF (dry, 15 ml) followed by 5 -phenyl- lH-pyrazole-3-carboxylic acid (97mg, 0.52 mmol). The resulting mixture was stirred at rt for 48h. The solvent was removed in vacuo and the remaining solid was purified by flash column chromatography (heptane/EtOAc 100/0 to 0/100) and triturated from DMSO:CH3CN:water 1 :2: 1 to obtain 63mg (18%) of N-{4-[(4,6-dimethylpyrimidin-2-yl)({[2- (trimethylsilyl)ethoxy]methyl} )sulfamoyl]phenyl } -3 -phenyl- 1 H-pyrazole-5 -carboxamide 10.2 as a pale yellow solid.

Statistics shows that 5-Phenyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5071-61-4.

Reference:
Patent; RAZE THERAPEUTICS, INC.; SAIAH, Eddine; (148 pag.)WO2016/40449; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Phenyl-1H-pyrazole-3-carboxylic acid

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Doma, Anuradha; Kulkarni, Ravindra; Palakodety, Radhakrishna; Sastry, G. Narahari; Sridhara, Janardhan; Garlapati, Achaiah; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 6209 – 6219;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 5071-61-4, These common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2B: Synthesis of l-(5-phenyl-lH-pyrazole-3-carbonyl)-N-(pyrimidin-2-yl)- N-{[2-(trimethylsilyl)ethoxy]methyl}-2,3-dihydro-lH-indole-5-sulfonamide 37.1 [00464] DIPEA (0.16 ml, 0.89 mmol) and HATU (170mg, 0.45 mmol) were added at rt to a stirred solution of 5 -phenyl- lH-pyrazole-3-carboxylic acid (60mg, 0.30 mmol) in DMF (HPLC grade, 10ml) followed by N-(pyrimidin-2-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}-2,3-dihydro- lH-indole-5 -sulfonamide (34.1, 120mg, 0.30 mmol). The mixture was stirred for 27h at rt then re-treated with 5 -phenyl- lH-pyrazole-3-carboxylic acid (30mg, 0.15 mmol), DIPEA (0.20 ml, 1.1 mmol) and HATU (220mg, 0.58 mmol) and stirred for 74h at rt. The solvent was removed in vacuo and the crude product purified by prep HPLC (MeCN/Water, 2mM ammonium bicarbonate) to afford 46mg (27%) of 1 -(5 -phenyl- lH-pyrazole-3 -carbonyl)-N-(pyrimidin-2-yl)- N-{[2-(trimethylsilyl)ethoxy]methyl}-2,3-dihydro-lH-indole-5-sulfonamide 37.1 as an off-white solid.

The synthetic route of 5071-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RAZE THERAPEUTICS, INC.; SAIAH, Eddine; (148 pag.)WO2016/40449; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 5071-61-4, The chemical industry reduces the impact on the environment during synthesis 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Phenyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Doma, Anuradha; Kulkarni, Ravindra; Palakodety, Radhakrishna; Sastry, G. Narahari; Sridhara, Janardhan; Garlapati, Achaiah; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 6209 – 6219;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5071-61-4, Product Details of 5071-61-4

To a solution containing 0.31 g (1.65 mmol) of 5-phenyl-1H-pyrazole-3-carboxylic acid and 3 mL of DMF was added 0.77 g (1.82 mmol) of COMU, 0.28 g (1.73 mmol) of tert-butyl(3-aminopropyl)carbamate, and 0.45 mL (2.5 mmol) of DIPEA. The reaction mixture was allowed to stir at rt overnight, quenched by the addition of 10% HCl in water, and extracted with DCM. The combined organic layers were dried by passage through a phase separator cartridge and the solvent was removed under reduced pressure. The residue was subjected to silica gel chromatography to give 0.59 g (100%) of tert-butyl (3-(5-phenyl-1H-pyrazole-3-carboxamido)propyl)carbamate as a yellow oily solid. LC/MS ret. time=1.124 min, m/z=289.30 [M-C(CH3)3]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Phenyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; Lindsley, Craig W.; Waterson, Alex G.; Beauchamp, R. Daniel; (77 pag.)US2016/52896; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5071-61-4 as follows. SDS of cas: 5071-61-4

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

According to the analysis of related databases, 5071-61-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Doma, Anuradha; Kulkarni, Ravindra; Palakodety, Radhakrishna; Sastry, G. Narahari; Sridhara, Janardhan; Garlapati, Achaiah; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 6209 – 6219;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H8N2O2

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5071-61-4.

Reference:
Article; Doma, Anuradha; Kulkarni, Ravindra; Palakodety, Radhakrishna; Sastry, G. Narahari; Sridhara, Janardhan; Garlapati, Achaiah; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 6209 – 6219;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 5071-61-4, These common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2A: Synthesis of N-{4-[(4,6-dimethylpyrimidin-2-yl)({[2- (trimethylsilyl)ethoxy] methyl}) sulfamoyl]phenyl}-3-phenyl-lH-pyrazole-5-carboxamide, 10.2 [00292] HATU (294mg, 0.77 mmol) and DIPEA (0.27 ml, 1.55 mmol) were added at rt to a stirred solution of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-N-{[2- (trimethylsilyl)ethoxy]methyl}benzene-l-sulfonamide (10.1, 211 mg, 0.52 mmol) in DMF (dry, 15 ml) followed by 5 -phenyl- lH-pyrazole-3-carboxylic acid (97mg, 0.52 mmol). The resulting mixture was stirred at rt for 48h. The solvent was removed in vacuo and the remaining solid was purified by flash column chromatography (heptane/EtOAc 100/0 to 0/100) and triturated from DMSO:CH3CN:water 1 :2: 1 to obtain 63mg (18%) of N-{4-[(4,6-dimethylpyrimidin-2-yl)({[2- (trimethylsilyl)ethoxy]methyl} )sulfamoyl]phenyl } -3 -phenyl- 1 H-pyrazole-5 -carboxamide 10.2 as a pale yellow solid.

Statistics shows that 5-Phenyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5071-61-4.

Reference:
Patent; RAZE THERAPEUTICS, INC.; SAIAH, Eddine; (148 pag.)WO2016/40449; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 5071-61-4,Some common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of intermediate 12-g (1.2 g, 2.30 mmol) in DMF, cooled to 0 C., were sequentially added 5-phenyl-1H-pyrazole-3-carboxylic acid (455 mg, 2.42 mmol), HATU (1.0 g, 2.77 mmol) and DIPEA (1.60 mL, 9.22 mmol) and the reaction mixture was stirred at 0 C. for 2 hours. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous ammonium chloride, saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 62-a as a white solid.

The synthetic route of 5071-61-4 has been constantly updated, and we look forward to future research findings.