Tag: M.W=0-100

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35277-02-2, name is 4-Fluoro-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 4-Fluoro-1H-pyrazole

4-Fluoro-1H-pyrazole (4.73 g, 55 mmol) and potassium carbonate (17.27 g, 125 mmol) were combined and stirred in N,N-dimethylformamide (41.7 mL) for 10 minutes in an open sealed tube before addition of 2-bromo-5-acetylpyridine (10 g, 50 mmol). The reaction tube was sealed and stirred 20 hours at 100C. The reaction mixture was then cooled to room temperature and poured into water (700 mL). The mixture was sonicated and stirred for 20 minutes. A beige solid was isolated by filtration, washed with small amounts of water, and dried to yield 1-(6-(4-fluoro-1H- pyrazol-1-yl)pyridin-3-yl)ethan-1-one (9.81 g, 96% yield). MS: M+1 = 206.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 31108-57-3,Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of II-C7 (70 mg, 0.15 mmol) in acetone (5 mL) were added K2C03 (41 mg, 0.3 mmol) and lH-pyrazole-4-carbonitrile (28 mg, 0.3 mmol) at l5C. The reaction mixture was stirred for 16 hours at l5C. The reaction mixture was added into saturated NH4CI (50 mL), and the aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic layer was washed with saturated brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated to give product. The residue was purified by combi flash (0-20% of EtOAc in PE) to give II-C8 (45 mg, 63%) as a solid. (1075) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 5.02 (d, 7= 18.0 Hz, 2H), 4.89 (d, J= 18.0 Hz, 2H), 3.54 (q, J= 6.8 Hz, 2H), 3.41 (q, J= 9.2 Hz, 2H), 2.75 (s, 1H), 2.63-2.53 (m, 1H), 2.25-2.10 (m, 1H), 2.09-1.85 (m, 2H), 1.80-1.58 (m, 7H), 1.51-1.25 (m, 11H), 1.24- 1.10 (m, 6H), 0.78 (t, J= 7.2 Hz, 3H), 0.64 (s, 3H); MS ESI calcd. for C29H42N302 [M+H- H20]+ 464, found 464.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Pyrazole-4-carbonitrile, its application will become more common.

Application of 31230-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Degassed toluene (6 ml) and EtOH (3 ml) were added in one portion to a mixture of 4-bromo-2-phenyl-2H-phthalazin-1-one (0.750 g, 2.5 mmol), sodium t-butoxide (0.337 g, 3.5 mmol), 3-amino-5-methyl pyrazole (0.291 g, 3 mmol), tris-(dibenzylideneacetone)-dipalladium (0.115 g, 0.125 mmol) and 2- (di- t-butylphosphino)-biphenyl (0.075 g, 0.25 mmol) under nitrogen. The reaction mixture was heated to 100¡ã C. for 20 hours with stirring and then cooled to RT. Diethyl ether (10 ml) was added and the precipitated solid was filtered to give the crude product as a grey solid (0.6 g, 76percent yield). A 0.06 g portion of the crude product was triturated with MeCN (2 ml) and water (2 ml) to give the target compound (0.045 g, 58percent yield based on recovered materials). 1H-NMR: (400 MHz, D6-DMSO) 11.96 (1H, s), 9.33 (1H, s), 8.53 (1H, d), 8.38 (1H, d), 7.92-7.99 (2H, m), 7.88 (2H, d), 7.77 (2H, t) 7.34 (1H, t) 6.24 (1H, s) 2.18 (3H, s) MS (ESI+)=(M+H)+ 318.29.

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Reference of 132712-71-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The chemical industry reduces the impact on the environment during synthesis 3-Methyl-1H-pyrazol-5-ol. I believe this compound will play a more active role in future production and life.

Reference of 35344-95-7, The chemical industry reduces the impact on the environment during synthesis 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

1H-pyrazole-4-carbaldehyde (0.5 g; 5.2 mmol) and cesium carbonate (3.39 g; 10.4mmol) were diluted in ACN (10 mL). Then, 2-bromoethyl methyl ether (0.636 mL; 6.77 mmol) was added and the reaction mixture was refluxed for 2 hours. The reaction mixture was partitionned between a saturated solution of NaHCO3 and EtOAc. The organic layer was separated, dried over MgSO4, filtered and concentrated.The residue was purified by silica gel chromatography (irregular Si02, 120 g, DCM/MeOH: 100/0 to 95/5). The fractions containing the product were mixed andconcentrated to afford 439 mg (55percent) of intermediate 35.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, Formula: C4H4N2O

A mixture of 8-(1 -methyl-1 H-indol-6-yl)-quinoxalin-6-ylamine (Intermediate 22) (100.00 mg; 0.34 mmol; 1 .00 eqr.), 1 H-pyrazole-4-carbaldehyde (41.89 mg; 0.44 mmol; 1.30 eg.) and CH3COOH (0.10 ml1.75 mmol; 5.22 eq.) in 1 ,2-dichloroethane (5.00 ml_) under argon at 5¡ãC is stirred for 10 min and next 1 h at rt. After this time, RM is cooled to 5¡ãC and NaBH(OAc)3 (96.80 mg; 0.44 mmol; 1.30 eq.) is added and then RM is stirred at rt overnight. RM is diluted with water and extracted with EtOAc. Combined organic layers are washed with brine, dried over Na2S04, filtered and evaporated. Brown residue is purified by FCC (DCM/MeOH; gradient) and repurified by preparative HPLC. 8-(1 -methyl-1 H-indol-6-yl)-N-(1 H-pyrazol-4- ylmethyl)quinoxalin-6-amine (55.00 mg; yield 46 percent; 99 percent by HPLC) as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Related Products of 35344-95-7, These common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1H- pyrazole-4-carbaldehyde (1.73 g, 18.00 mmol, 1.20 eq.) and Cs2CO3 (9.78 g, 30.02 mmol, 2.00 eq.) were added to a solution of tert-butyl N-[3-(methanesulfonyloxy)cyclobutyl]carbamate (4 g, 15.08 mmol, 1.00 eq.) in DMF (100 mL). The resulting solution was stirred for 16 hours at 80 C and then diluted with 300 mL of water. The resulting solution was extracted with ethyl acetate (3×300 mL) and the organic layers combined. The resulting mixture was washed with brine (3×500 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified by Flash with the following conditions: Column, C18 silica gel; mobile phase, X:H20 Y_ACN=70/30 increasing to X:H20 Y_ACN=20/80 within 30 mm;Detector, UV 254 nm. The isomers were separated by Prep-SFC with the following conditions (Prep SFC8O-2): Column, Chiralpak TB, 2*25cm, 5um; mobile phase, CO2 (80%), IPA (20%); Detector, UV 220nm. This resulted in 1.2 g (30%) of tert-butyl N-trans-3-(4-formyl-1H- pyrazol-1-yl)cyclobutyl]carbamate as a white solid.

The synthetic route of 35344-95-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H7N3

General procedure: A solution of beta-bromovinyl aldehyde 1 (1.0 mmol), aminopyrazole 2 (1.0 mmol), Pd(OAc)2 (5molpercent), PPh3 (10 molpercent) and K2CO3(1.2 mmol) in DMF (1.0 mL) was irradiated in a closed vessel in a Synthos 3000 microwave reactor at 700 Watt (120 oC and 14 bar) for 20 minutes. After completion of the reaction, the reaction mixture was treated with water (30 mL) and then extracted with ethylacetate (30 x 3 mL). The organic portion was washed with water, dried over anhydrous sodium sulfate and the solvent was removed in vacuo to obtain a crude product which on silica gel column chromatographic purification using EtOAc/hexane as the eluent afforded compounds 3a-l.

The synthetic route of 31230-17-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 31230-17-8,Some common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1) Weigh 2,4,6-trichloropyrimidine (1.83 g, 10 mmol)And 3-amino-5-methylpyrazole (0.97 g, 10 mmol) dissolved in 100 mL of absolute ethanol,Add triethylamine (2.7 mL, 20 mmol), and stir the reaction at 0 C for 12 h;2) After stopping the reaction,Add 150 mL of water to the reaction solution.A large amount of white solid was precipitated immediately.Filtering,The solid was washed sequentially with 50 mL of ice water and 20 mL of ice methanol.After drying, Intermediate 1 (1.82 g, yield 75%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazol-3-amine, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2817-71-2 as follows. Application In Synthesis of 1-Ethylpyrazole

Weigh 0.05 mol of 1-ethyl-1-H-pyrazole (4.8 g) and 0.05 mol of 3-bromopropylamine hydrobromide (10.946 g)Add to a three-necked flask, add 20 mL of absolute ethanol as a solvent, and stir at 80 C for 72 h.After cooling to room temperature, a white solid was separated from anhydrous ethanol, filtered, washed three times with 10 mL of anhydrous ethanol, and dried in a vacuum oven overnight to give a white powder solid.3.15 g of a white powder solid was dissolved in 10 mL of distilled water, the pH was adjusted to about 9 with KOH, and stirred at room temperature for 30 minutes, and then the water in the system was removed with cyclohexane.Pour out cyclohexane.The mixture was extracted with a mixed solution of tetrahydrofuran and methanol, and the inorganic salt solid was removed by filtration, and the obtained liquid was concentrated to give a yellow viscous liquid, yield: 85.16%.

According to the analysis of related databases, 2817-71-2, the application of this compound in the production field has become more and more popular.