Related Products of 31108-57-3,Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of II-C7 (70 mg, 0.15 mmol) in acetone (5 mL) were added K2C03 (41 mg, 0.3 mmol) and lH-pyrazole-4-carbonitrile (28 mg, 0.3 mmol) at l5C. The reaction mixture was stirred for 16 hours at l5C. The reaction mixture was added into saturated NH4CI (50 mL), and the aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic layer was washed with saturated brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated to give product. The residue was purified by combi flash (0-20% of EtOAc in PE) to give II-C8 (45 mg, 63%) as a solid. (1075) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 5.02 (d, 7= 18.0 Hz, 2H), 4.89 (d, J= 18.0 Hz, 2H), 3.54 (q, J= 6.8 Hz, 2H), 3.41 (q, J= 9.2 Hz, 2H), 2.75 (s, 1H), 2.63-2.53 (m, 1H), 2.25-2.10 (m, 1H), 2.09-1.85 (m, 2H), 1.80-1.58 (m, 7H), 1.51-1.25 (m, 11H), 1.24- 1.10 (m, 6H), 0.78 (t, J= 7.2 Hz, 3H), 0.64 (s, 3H); MS ESI calcd. for C29H42N302 [M+H- H20]+ 464, found 464.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Pyrazole-4-carbonitrile, its application will become more common.