Tag: M.W=0-100

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3920-50-1, name is Pyrazole-3-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Pyrazole-3-carboxaldehyde

General procedure: A mixture of 1H-imidazole-2-carbaldehyde 40 (200 mg, 2.08 mmol), potassium carbonate (0.8630 g, 6.24 mmol) and 3-(bromomethyl)-1,1′-biphenyl 38 (0.7716 g, 3.12 mmol) in acetonitrile (10 mL) was stirred overnight at room temperature, then the solvent was removed, diluted with water, and extracted with ethyl acetate (3 x 30 mL). The combined organic phases were washed with brine, dried with Na2SO4, filtered, concentrated and purified by silica gel chromatography to afford 44 as a pale yellow solid (527 mg, 97%).

According to the analysis of related databases, 3920-50-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Quality Control of 1H-Pyrazole-4-carbaldehyde

To a stirred solution of iFi-pyrazole-4carbaldehyde (1.00 g, 10.41 mmoi) in MeOH (20 mL) was added acetic acid (0.60 mL, 10.41 mrnol), Intermediate 74 (2.59 g, 12.49 mmol) andthe reaction mixture was stirred at ambient temperature for 20 miii. Then NaCNI3H4 (1 .96 g,3 1.2 mmol) was added and stirring was continued at ambient temperature for 14 h. The reaction mixture was distilled under reduced pressure and basified with saturated sodium bicarbonate solution (50 mL). To the resulting aqueous mixture was added BOC2O (2.34 ml, 10.09 mniol) and stirred at ambient temperature for 2. h. The reaction mixture was diluted with water (20 mL) and extracted with 5percent mnethanoi:DCM (3 x 30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-24 g, 4percent MeOHJCHCI3), to obtainintermediate 721 (095 g, 24.29percent). ?HNMR (300 MHz, DMSO-d6) 8 ppm 1.23 1.46 (in, 9 H)1.57 (s, I H) 2.26 (hr. s., 3 H) 308 – 3.26 (in, I H) 4.21 4.32 (m, 2 H) 5.07 – 5.19 (in, I H) 5.37(s, 2 H) 5.59 -5.71 (m, I H) 7.31 – 7.42 (m, I H) 7.69 (s, 3 H) 12.58- 12.73 (m, I H). LCMS(Method?H;): retention time 1.29 mm. [M-Hj 388.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1H-Pyrazole-4-carbonitrile

To a solution of crude reactant SC-II (100 mg, 0.241 mmol) in anhydrous THF (5 mL) was added lH-pyrazole-4-carbonitrile (112 mg, 1.2 mmol) followed by potassium carbonate (170 mg, 1.2 mmol) and the solution was heated at 60 C for 2h. Then the reaction mixture was diluted with ethyl acetate (100 mL). The resulting solution was washed with brine (2×50 mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by reverse phase prep-HPLC to afford product SB-21 (46 mg, 0.109 mmol, Yield=45%) as a white solid. 1HNMR (500 MHz, CDC13) 5(ppm): 7.86 (IH, s), 7.81 (IH, s), 5.00 (IH, AB), 4.92 (IH, AB), 2.61 (IH, t), 0.67 (3H, s), 0.67-2.25 (24H, m). LCMS: rt=2.47 mm, /z=424.2 [M+H]+

According to the analysis of related databases, 31108-57-3, the application of this compound in the production field has become more and more popular.

Application of 31108-57-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31108-57-3 as follows.

General procedure: Prepared according General Procedure B from compound All (25 mg, 0.057 mmol) and 5- chlorotriazole (106 mg, 1.14 mmol), with purification by reverse phase preparative HPLC to provide compound 13 as a white solid (16.8 mg, 65%): mp 141-142 C; 1HNMR (500 MHz, CDC13) delta 7.85 (s, IH), 7.80 (s, IH), 4.95 (dd, J= 62.5, 17.5 Hz, 2H), 3.47 (dd, J= 10.0 Hz, IH), 3.37 (dd, J = 10.0 Hz, IH), 3.28 (s, 3H), 2.60 (t, J = 9.0 Hz, IH), 2.23-2.20 (m, IH), 2.05-2.01 (m, 2H), 1.76-1.69 (m, 4H), 1.63-1.49 (m, 7H), 1.47-1.10 (m, 10H), 0.99-0.97 (m, 1H), 0.87-0.85 (m, 1H), 0.69 (s, 3H) ppm; ESI MS m/z 436 [M+H-H20]+ .

According to the analysis of related databases, 31108-57-3, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-36-9, name is 1-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 930-36-9

A mixture of 1-methyl-1H-pyrazole (7) (37 gm, 0.6090 moles), iodine (57.1 gm,0.225 moles), hydrogen peroxide (9.2 gm, 0.27 moles) and DI water (I 10 ml) were stirred for 24 hour at 20-30C. Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 5-10C. The reaction mixture was quenched with 20% aqueous sodium bisulfate (100 ml) and stirred for I hour at 5-10C. The solid obtained was filtered,V washed with cold DI water (100 ml) and dried at 40-45C to obtain the product, 4-iodo-1-methyl- 1H-pyrazole. VDrywt : 56gmYield : 1.51 w/w(60%) V

The synthetic route of 930-36-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-13-1, name is 1H-Pyrazole, A new synthetic method of this compound is introduced below., Product Details of 288-13-1

To a solution of pyrazole (10.0 g, 147 mmol) in dichloromethane (150 mL), triethylamine (26.6 mL, 192 mmol) and N,N-dimethylsulfamoyl chloride (20.0 mL, 181 mmol) were added and the reaction mixture was heated to reflux for approximately 60 h. The reaction mixture was then cooled to ambient temperature and filtered through a pad of silica gel using dichloromethane as an eluent. The filtrate was then concentrated under reduced pressure and treated with diethyl ether (100 mL) resulting in the formation of a solid. The suspension was filtered, and the precipitate was washed with diethyl ether. The combined filtrates were combined and concentrated in vacuo to give 27.46 g of the title compound. This compound was of sufficient purity to use in subsequent reactions. 1H NMR (CDCl3) delta 2.94 (s, 6H), 6.40 (s, IH), 7.75 (s, IH), 7.99 (s, IH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 694-48-4, name is 1,3-Dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 694-48-4, Recommanded Product: 1,3-Dimethyl-1H-pyrazole

In a three-necked reaction flask equipped with a stirrer, 50 ml of acetic anhydride and 12.7 g of nitric acid were added,1,3-dimethylpyrazole 9.7 g of acetic anhydride in 10 ml was slowly added dropwise to the mixed acid,Add 50-60 degrees after the end of the reaction until the reaction is complete,Cooled to room temperature to add 100 grams of ice water,Filtered and dried to give 12 g of 4-nitro-1,3-dimethylpyrazole,LC purity 80%, yield: 84%.

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Methyl-1H-pyrazol-5-amine

(3 S)-7-(2-Chloro-5-methylpyrimidin-4-yl)-3-methyl-2-((2-methylpyrimidin-4-yl)methyl)- 3 ,4-dihydropyrrolo [1 ,2-a]pyrazin- 1 (2H)-one (122 mg, 0.32 mmol), i-methyl-i H-pyrazol5-amine (37.1 mg, 0.38 mmol) and cesium carbonate (228 mg, 0.70 mmol) were suspended in tert-butanol (2 mL) and de-gassed with nitrogen for 5 minutes, then BrettPhos 3rd generation pre-catalyst (14.44 mg, 0.02 mmol) was added. The reaction was heated to100 °C in the microwave for 1 hour, then allowed to cool to ambient temperature, diluted with DCM (30m1), washed with brine (30m1), separated, dried (MgSO4) and evaporated to afford crude product, which was purified by preparative HPLC (Waters XBridge Prep Ci 8 OBD column, Sji silica, 30 mm diameter, 100 mm length), using decreasingly polar mixtures of water (containing 1percent NH3) and MeCN as eluents. Fractions containing thedesired compound were evaporated to dryness to afford (3S)-3-methyl-7-(5-methyl-2-((i- methyl-i H-pyrazol-5 -yl)amino)pyrimidin-4-yl)-2-((2-methylpyrimidin-4-yl)methyl)-3 ,4- dihydropyrrolo[i,2-a]pyrazin-i(2H)-one (67.2 mg, 47.5 percent) as a pale yellow gum. 1H NMR (500 MHz, DMSO, 30 °C) 1.20 (3H, d), 2.34 (3H, s), 2.62 (3H, s), 3.70 (3H, s), 3.97 – 4.05 (iH, m), 4.24 (iH, dd), 4.34 (iH, d), 4.47 (iH, dd), 5.10 (iH, d), 6.27 (iH, d), 7.27 (iH,d), 7.29 (iH, d), 7.34 (iH, d), 7.69 (iH, d), 8.25 (iH, s), 8.63 (iH, d), 9.09 (iH, s). mlz:ES+ [M+H]+ 444.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1192-21-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Methyl-1H-pyrazol-3-amine

Intermediate 14; 2-Chloro-5 -methyl-N-(5 -methyl- lH-pyrazol-3-yl)pyrimidin-4-amine2,4-Dichloro-5-methylpyrimidine (2.395 g, 14.69 mmol), 5 -methyl- lH-pyrazo 1-3 -amine (1.710 g,17.61 mmol), and DIPEA (3.80 g, 29.39 mmol) in ethanol (20 ml) was heated at 6O0C over the weekend. LCMS indicated complete reaction. Solvent was removed under reduced pressure and the residue was purified by ISCO (5percentMeOH/0.5percent NH4OH in CH2Cl2. 2.5g (76percent) of the title compound was isolated.1H NMR (400 MHz, DMSO-d6) delta ppm 12.17 (s, 1 H) 9.30 (s, 1 H) 7.97 (s, 1 H) 6.37 (s, 1 H) 2.25 (s, 3 H) 2.13 (s, 3 H). LCMS: 224 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31230-17-8.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-31-0 as follows. category: pyrazoles-derivatives

Example Q (0350) 4-(((4-(4-Fluorophenyl)pyridin-2-yl)(1 -methyl-1 H-pyrazol-3-yl)amino)methyl)-N- hy (0351) (0352) Q 2- Chloro-4-(4-fluorophenyl)pyridine (1 ) (1.0g, 4.8mmol), 1 -methyl- 1 H-pyrazol-3- amine (2) (470mg, 4.8mmol), Xantphos (0.28g, 0.48mmol) and Cs2C03 (2.35g, 7.24mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10min. Pd2(dba)3 (0.22g, 0.24mmol) was then added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralised water (200ml_) and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1) to provide 4-(4-fluorophenyl)-N-(1-methyl- 1 H-pyrazol-3-yl)pyridin-2-amine (3) as a yellow solid (1.0g, 71 percent). (0353) LCMS (ES): Found 269.1 [M+H]+.

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.