Application of 31108-57-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31108-57-3 as follows.
General procedure: Prepared according General Procedure B from compound All (25 mg, 0.057 mmol) and 5- chlorotriazole (106 mg, 1.14 mmol), with purification by reverse phase preparative HPLC to provide compound 13 as a white solid (16.8 mg, 65%): mp 141-142 C; 1HNMR (500 MHz, CDC13) delta 7.85 (s, IH), 7.80 (s, IH), 4.95 (dd, J= 62.5, 17.5 Hz, 2H), 3.47 (dd, J= 10.0 Hz, IH), 3.37 (dd, J = 10.0 Hz, IH), 3.28 (s, 3H), 2.60 (t, J = 9.0 Hz, IH), 2.23-2.20 (m, IH), 2.05-2.01 (m, 2H), 1.76-1.69 (m, 4H), 1.63-1.49 (m, 7H), 1.47-1.10 (m, 10H), 0.99-0.97 (m, 1H), 0.87-0.85 (m, 1H), 0.69 (s, 3H) ppm; ESI MS m/z 436 [M+H-H20]+ .
According to the analysis of related databases, 31108-57-3, the application of this compound in the production field has become more and more popular.