Tag: 100-200

A facile synthesis, structure, and antimicrobial evaluation of novel 4-arylhydrazono-5-trifluoromethyl-2,4-dihydropyrazol-3-ones, their N- and N,O-bis-β-D-glucosides was written by Khalil, Nasser S. A. M.. And the article was included in Carbohydrate Research in 2009.Related Products of 401-73-0 This article mentions the following:

Synthesis of some novel 4-arylhydrazono-5-trifluoromethyl-2,4-dihydropyrazol-3-ones, their N- and N,O-bis- β-D-glucosides, e.g. I, is described. Antimicrobial evaluation of eight selected compounds against Aspergillus fumigatus RCMB 002008 (1), Penicillium italicum RCMB 001018 (1), Syncephalastrum racemosum RCMB 016001, Candida albicans RCMB 005003, Staphylococcus aureus RCMB 106-001 (1), Pseudomonas aeruginosa RCMB 102-002, Bacillus subtilis RCMB 101-001, and Escherichia coli RCMB 103-001 has been achieved. The screening results indicated that all the tested compounds exhibited different inhibitory effects against five to seven different organisms of the eight test organisms. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Related Products of 401-73-0).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Related Products of 401-73-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A mild and efficient method for halogenation of 3,5-dimethyl pyrazoles by ultrasound irradiation using N-halosuccinimides was written by Stefani, Helio A.;Pereira, Claudio M. P.;Almeida, Roberta B.;Braga, Rodolpho C.;Guzen, Karla P.;Cella, Rodrigo. And the article was included in Tetrahedron Letters in 2005.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The 4-halo-3,5-dimethyl pyrazoles were synthesized in good yields in short reaction times in the absence of a catalyst by reaction of 3,5-di-Me pyrazoles with N-halosuccinimides (NBS, NCS and NIS) under ultrasound irradiation Finally, the halogenation of pyrazoles with Br₂, ICl and I₂ was showed in similar conditions. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Multimolecular Complexes of CL-20 with Nitropyrazole Derivatives: Geometric, Electronic Structure, and Stability was written by Zhu, Shuang-fei;Gan, Qiang;Feng, Changgen. And the article was included in ACS Omega in 2019.Application In Synthesis of 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:

The multimol. complexes formed between 2,4,6,8,10,12-hexanitro-2,4,6,6,8,10,12-hexaazaisowurtzitane (CL-20) and nitropyrazole compounds were investigated using B3LYP-D3/6-311G(d,p) and B97-3c methods. CL-20 in these complexes was surrounded by Me, nitro, and amino derivatives of 4-nitropyrazole. The influence of substituents on the mol. electrostatic potential distribution of nitropyrazoles was investigated to figure out the potential electrostatic interaction sites. For the complex, the O···H hydrogen bond was popular in the intermol. interactions, and dispersion interaction played an essential role, especially in Cx/CL-20 multimol. complexes. Trigger bond anal. showed that their strength increased upon the formation of intermol. weak interactions. Nitro group charge calculations stated that the neg. charge on almost all nitro groups showed a significant increase. Therefore, the sensitivity of CL-20 seemed to be lower than the original. In addition, the transfer of electron d. between CL-20 and nitropyrzoles in complexes was investigated, revealing the influence of weak interactions on the electron d. of CL-20. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Application In Synthesis of 3-Methyl-4-nitro-1H-pyrazole).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 3-Methyl-4-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Spectroscopic and electrochemical properties of o-amino-1-methylnitropyrazoles was written by Perevalov, V. P.;Baryshnenkova, L. I.;Sennikov, G. P.;Savina, I. B.;Isaev, Sh. G.;Andreeva, M. A.;Stepanov, B. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1985.Product Details of 54210-32-1 This article mentions the following:

The electronic, IR, and NMR spectra and the polarog. half-wave potentials of pyrazoloes I (R, R¹, R² = H, NH, NO₂; NO₂, NH₂, H; NH₂, NO₂, H; H, NO₂, NH₂) were examined These properties were influenced by the degree of charge transfer between the NH₂ and NO₂ groups. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Product Details of 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A new procedure for the synthesis of 4H-pyrazolo[1,5-c][1,3,5]thiadiazine-4-thiones was written by Vicentini, C. B.;Veronese, A. C.;Guarneri, M.;Manfrini, M.;Giori, P.;Guccione, S.. And the article was included in Journal of Heterocyclic Chemistry in 1994.Product Details of 141459-53-2 This article mentions the following:

Thiation of pyrazolyl amides I (R = alkyl, 4-halophenyl; R¹ = CMe₃; X = O) by the Lawesson reagent afforded I (same R, R¹; X = S). Heating the thiocarboxamides in formic acid gave the N-dealkylated thiocarboxamides (I; R = alkyl, 4-halophenyl; R¹ = H; X = S), which were cyclized with thiophosgene to give the title compounds (II). In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Product Details of 141459-53-2).

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 141459-53-2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Studies on absorption spectra of newly synthesized cyanine dyes was written by Abu El-Hamd, Ragab M.. And the article was included in Indian Journal of Heterocyclic Chemistry in 1996.Application In Synthesis of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:

New asym. monomethine cyanines (I; R = H, Ph; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), trimethine cyanines (II; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), and styryl cyanines (III; R = H, OMe, NO₂; X = NH, CH₂; A = H, C₄H₄) were synthesized to study their spectral behavior, solvatochromism, mixed solvents and acid-base properties. These dyes are characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Application In Synthesis of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Influence of nitropyrazoles on the gel effect during the radical polymerization of methyl methacrylate in bulk was written by Jovanovic, S.;Stankovic, R.;Jovic, D.;Kosanovic, D.;Dumanovic, D.. And the article was included in Journal of the Serbian Chemical Society in 1992.Quality Control of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

The effect of different nitropyrazoles on the course of the bulk radical polymerization of Me methacrylate (I) was investigated. At low degrees of conversion of I to poly(Me methacrylate), the nitropyrazoles under consideration acted as retarders and at high degrees of conversion as inhibitors. Some of the nitropyrazoles were such efficient retarders for I polymerization that they completely suppressed the autoacceleration of polymerization, i.e., the gel effect. The activity of the pyrazole derivatives as retarders for the radical polymerization of I in bulk depends on the number and position of nitro and other groups introduced into the pyrazole ring. The half-wave potential of the studied nitropyrazoles could be used as a measure of their activity as a retarder. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Quality Control of 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Quality Control of 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:

A new series of quinazolinyloxy- and quinazolinylamonopyrazoleacetamides which inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932 (I). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Quality Control of 1-Ethyl-1H-pyrazol-3-amine).

1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Quality Control of 1-Ethyl-1H-pyrazol-3-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of heterocyclic systems with a carbohydrate fragment. 1. Stereoselective synthesis of azolo anhydro sugars by addition of azoles to levoglucosenone was written by Samet, A. V.;Laichter, A. L.;Reznikov, D. N.;Yamskov, A. N.;Ugrak, B. I.;Chernyshova, N. B.;Yolkin, V. V.;Semenov, V. V.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1994.Recommanded Product: 5334-39-4 This article mentions the following:

Levoglucosenone (I) reacts with NH-azoles in the presence of bases to give Michael adducts, e.g., II (Az = 3-nitropyrazol-1-yl, 5-nitrotetrazol-2-yl), and in some cases their hydrates (gem-diols) also. In all cases the addition proceeds stereospecifically and with good yields. 3-Nitro-s-triazole, 3- and 4-nitropyrazole, 3-methyl-4-nitropyrazole, 5-nitrotetrazole, 4,5-dicarbomethoxy-v-triazole, 3,4-dinitropyrazole, 3(5)-methylpyrazole, pyrazole and imidazole are used in this reaction. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Recommanded Product: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Azoles. XIII. Nuclear magnetic resonance spectra of pyrazoles was written by Elguero, Jose;Jacquier, Robert;Nguyen Tien Duc Hong Cung. And the article was included in Bulletin de la Societe Chimique de France in 1966.Electric Literature of C5H7ClN2 This article mentions the following:

The N.M.R. spectra of 180 pyrazoles in nonaqueous solvents (CDCl3, CCl4, C6H6, Me2SO, CF3CO2H) were analyzed. Classes represented were non-N-substituted, N-alkyl (especially N-Me), N-carboxamide, N-tosyl, N-Ph, N-p-nitrophenyl, N-(2,4-dinitrophenyl), and 2,4,6-trinitrophenyl pyrazoles. Chem. displacements (τ) and coupling constants (J) were calculated and compared with literature values. Differences in values were attributed to substituents in ring positions 3, 4, and 5. Steric hindrance between the pyrazolic nucleus and aromatic substituents and the effect of C-Me groups on shielding of the pyrazolic protons was studied. 85 references. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Electric Literature of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics