Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases was written by Ple, Patrick A.;Jung, Frederic;Ashton, Sue;Hennequin, Laurent;Laine, Romuald;Morgentin, Remy;Pasquet, Georges;Taylor, Sian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Quality Control of 1-Ethyl-1H-pyrazol-3-amine This article mentions the following:
A new series of quinazolinyloxy- and quinazolinylamonopyrazoleacetamides which inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932 (I). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Quality Control of 1-Ethyl-1H-pyrazol-3-amine).
1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Quality Control of 1-Ethyl-1H-pyrazol-3-amine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics