Influence of nitropyrazoles on the gel effect during the radical polymerization of methyl methacrylate in bulk was written by Jovanovic, S.;Stankovic, R.;Jovic, D.;Kosanovic, D.;Dumanovic, D.. And the article was included in Journal of the Serbian Chemical Society in 1992.Quality Control of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:
The effect of different nitropyrazoles on the course of the bulk radical polymerization of Me methacrylate (I) was investigated. At low degrees of conversion of I to poly(Me methacrylate), the nitropyrazoles under consideration acted as retarders and at high degrees of conversion as inhibitors. Some of the nitropyrazoles were such efficient retarders for I polymerization that they completely suppressed the autoacceleration of polymerization, i.e., the gel effect. The activity of the pyrazole derivatives as retarders for the radical polymerization of I in bulk depends on the number and position of nitro and other groups introduced into the pyrazole ring. The half-wave potential of the studied nitropyrazoles could be used as a measure of their activity as a retarder. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Quality Control of 1-Methyl-3-nitro-1H-pyrazole).
1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 1-Methyl-3-nitro-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics