Related Products of 1146629-77-7, The chemical industry reduces the impact on the environment during synthesis 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, I believe this compound will play a more active role in future production and life.
Add to a solution of 37 (400 mg, 1.34 mmol, prepared in Lin, Q. et al., Org. Lett., 2009, 11, 1999-2002) in acetonitrile (10 mL)36 (418 mg, 3.34 mmol),Then DBU (421 muL, 2.81 mmol) was added.The reaction was stirred at room temperature for 15 hours.It was then concentrated under reduced pressure. The crude mixture was diluted with water and extracted with EtOAc EtOAc. The organic layers were combined, washed with EtOAc EtOAc m.Purification by normal phase column chromatography (SiO2, 0-60% ethyl acetate / hexanes) and purified by reverse column chromatography (C18, 5-70% acetonitrile/water containing 0.1% formic acid) +/-) 38 (68 mg, 12%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kang Saite Pharmaceutical Pin Co., Ltd.; I ·R·xierfuman; J ·F·liu; A ·J·mogen; B ·pandeya; S ·L·habisen; (30 pag.)CN104725380; (2019); B;,
Pyrazole – Wikipedia,
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