These common heterocyclic compound, 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H8N2
To a solution of 6-chloronicotinonitrile (100 mg, 0.74 mmol) in DMF (2 mL), was added 3-cyclopropyl-1H-pyrazole (80 mg, 0.74 mmol), and Cs2CO3 (470 mg, 1.48 mmol). The mixture was stirred at 90C for 5 hours. To the mixture was added water and extracted with ethyl acetate. The organic layer was dried with anhydrous Na2SO4, and concentrated under vacuo to give 120 mg of 6-(3-cyclopropyl-1H-pyrazol-1-yl)nicotinonitrile as a light yellow solid. The structure was confirmed by LC-MS.
The synthetic route of 3-Cyclopropyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; FLEMING, Paul, E.; (62 pag.)WO2016/127074; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics