Application of 313735-62-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-bromo-l- (propan-2-yl)-lH-pyrazole (2 g, 10.58 mmol, 1.00 equiv) in Et20 (20 mL) maintained under nitrogen at -78 C was added dropwise a 2.5 M n-butyllithium solution (4.6 mL) in hexane. The reaction mixture was stirred at -78 C for 1 h. Sulfur dioxide gas was then bubbled in for 30 min. The reaction mixture was stirred at -78 C for 30 min and then warmed to rt. The solid was collected by filtration, washed with Et20 and dried in a vacuum to give 0.9 g (47%) of the title compound as a white solid. LCMS (Method G, ESI): RT =1.03 min, m/z = 191.0.
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-isopropylpyrazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; ZAK, Mark; ZHAO, Guiling; ZHENG, Xiaozhang; WO2014/74715; (2014); A1;,
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