Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., name: 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile
General procedure for diazotization of aminopyrazoles 1a-d and aminoimidazoles 2a-c: Aqueous NaNO2 (1.8 mmol, 1 mL) was added to a well-stirred and cooled solution (0-5 C) of pyrazole or imidazole (1 mmol) in a mixture of HCl/AcOH (3:1, 20 mL) over a period of 10 min. The reaction mixture was allowed to warm at room temperature and was stirred for 20 h. The precipitate of pyrazolotriazinone or imidazotriazinone was then filtered off, and the residue was diluted with water (20 mL), extracted with dichloromethane (3 × 30 mL), and dried with anhydrous MgSO4. The resulting solution was concentrated to dryness, and the solid was then subject to chromatographic column separation with dichloromethane and dichloromethane/ethyl acetate in different proportions.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Colomer, Juan Pablo; Moyano, Elizabeth Laura; Tetrahedron Letters; vol. 52; 14; (2011); p. 1561 – 1565;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics