Some common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, molecular formula is C5H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)-1H-pyrazole
A mixture of 13.02 g (0.1 mol) of 1-(2-chloroethyl)pyrazole 1, 11.2 g (0.2 mol) of KOH, and 50 mL of 50 wt% aqueous solution of MMO was vigorously stirred during 2 h at 80C. After cooling to ambient, the reaction mixture was extracted with chloroform. The solvent was removed, and the residue was distilled in vacuum. Yield 7.0 g (75%), bp 63C(50 mmHg), nD20 1.5160 [16]. IR spectrum, nu, cm-1:1520 (ring), 1640 (C=C). 1H NMR spectrum, delta, ppm(J, Hz): 5.00 d.d (1H, =CH2, J = 9.0, 1.5), 5.52 d.d(1H, =CH2, J = 15.8, 1.5), 6.26 t (1H, 4-H, J = 2.2),7.12 d.d (1H, NC=H, J = 15.8, 9.0), 7.50 d (1H, 3-H,J = 2.4), 7.58 d (1H, 5-H, J = 2.0).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96450-53-2, its application will become more common.