Reference of 1001020-13-8, The chemical industry reduces the impact on the environment during synthesis 1001020-13-8, name is (3-Trifluoromethyl-1H-pyrazol-4-yl)methanol, I believe this compound will play a more active role in future production and life.
(3-(Trifluoromethyl)-1H-pyrazol-4-yl)methanol (54.00 g, 0.325 mol) was suspended in toluene (2 L). MnO2 (113.00 g, 1.30 mol) and 4 molecular sieve powder (54.00 g) were added. The reaction mixture was stirred at reflux under nitrogen with a Dean-Stark trap for 5.5 h. The resulting mixture was filtered hot and the cake allowed to cool before washing with 1:1 DCM:MeOH solution (3×500 mL). The combined filtrates were concentrated in vacuo to give the desired product (54.00 g, 0.329 mol, 100%).1H NMR (400 MHz, DMSO): delta 8.72 (s, 1H), 9.91 (s, 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Trifluoromethyl-1H-pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.