25700-12-3, name is 3-(1H-Pyrazol-1-yl)pyridine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3-(1H-Pyrazol-1-yl)pyridine
Step 1: 3-(4-Bromopyrazol-1-yl)pyridine 3-Pyrazol-1-ylpyridine (500 mg, 3.44 mmol) was dissolved in acetonitrile (15 ml), and ammonium cerium(IV) nitrate (944 mg, 1.72 mmol) was added (slightly exothermic). N-Bromosuccinimide (736 mg, 4.13 mmol) was added a little at a time (slightly exothermic) and the mixture was stirred at room temperature for 30 min and then heated under reflux for 3 hours (h). After the mixture had cooled, ethyl acetate was added. The organic phase was washed with water, washed with a sodium sulphate solution and then dried with magnesium sulphate. The solvent was removed under reduced pressure using a rotary evaporator. Yield: 750 mg (93% of theory), logP(HCOOH) 1.56, [M++1] 224.0 1H-NMR (d6-DMSO): 7.54 (m, 1H), 7.90 (s, 1H), 8.20 (m, 1H), 8.55 (m, 1H), 8.79 (s, 1H), 9.06 (m, 1H).
The synthetic route of 25700-12-3 has been constantly updated, and we look forward to future research findings.