Introduction of a new synthetic route about Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Electric Literature of 21230-43-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21230-43-3, name is Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Compound 297; 2-Methyl-2,7-dihydropyrazolo[3,4-d]pyrimidine-4,6-dione; Compound 296 (2 g, 11.8 mmol) was melted at 200 C. with 6 g urea (large excess) for two hours. The reaction was permitted to cool to 40 C. and 20 mL water was added. The mixture was then boiled for 1 hour and stirred at room temperature overnight. Filtration and drying in vacuo afforded 1.86 g (95%) of a white solid. Compound 297: mp >300 C.; MS (ES+calculated: 166.14; found: 167.24 M+H). HPLC (100% purity, retention time 2.103 minutes-Method A); 1H NMR (400 MHz, DMSO-d6): 6 11.34 (br s, 1H), 10.66 (br s, 1H), 8.27 (s, 1H), 3.82 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.