Reference of 78208-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78208-72-7 name is Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of compound 14-4 (2.2 g, i2 mmol) in a mixed solvent of ethanol (10 mL) and water (5 mL) was added NaOH (1.9 g, 48 mmol). The mixture was stirred at rt for 3 hours. After the reaction was complete, the mixture was adjusted with hydrochloric acid (1 M) to pH 2 and concentrated in vacuo to remove ethanol. The mixture was diluted with water (50 mL). The resulting mixture was extracted with EtOAc (50 mL x 3). The combined organic layers were washed with saturated aqueous NaC1 solution, and dried over anhydrous Na2504 and concentrated in vacuo to give product 14-5 as a white solid (1.64 g, 88percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, and friends who are interested can also refer to it.