Category: 21230-43-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21230-43-3, name is Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 21230-43-3

(1) Synthesis of ethyl 3-chloro-1-methylpyrazole-4-carboxylate: Into a solution of 150 ml of conc. HCl, 50 ml of phosphoric acid (85%), 41.4 g of ethyl 3-amino-1-methylpyrazole-4-carboxylate and 100 ml of water, there was added dropwise a 50 ml of aqueous solution of 18.6 g of sodium nitrite at 0 C. or lower. The reaction mixture was added dropwise into a solution of 90 g of cupric sulfate (pentahydrate) and 60 g of sodium chloride dissolved in 200 ml of water at room temperature. The mixture was heated for an hour at 50 C. and after cooling, followed by extraction with chloroform. After washing with water and drying, evaporation of the solvent gave 44.8 g of ethyl 3-chloro-1-methylpyrazole-4-carboxylate. m.p.: 65-66 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nissan Chemical Industries, Ltd.; US4668277; (1987); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 21230-43-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21230-43-3, name is Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Compound 297; 2-Methyl-2,7-dihydropyrazolo[3,4-d]pyrimidine-4,6-dione; Compound 296 (2 g, 11.8 mmol) was melted at 200 C. with 6 g urea (large excess) for two hours. The reaction was permitted to cool to 40 C. and 20 mL water was added. The mixture was then boiled for 1 hour and stirred at room temperature overnight. Filtration and drying in vacuo afforded 1.86 g (95%) of a white solid. Compound 297: mp >300 C.; MS (ES+calculated: 166.14; found: 167.24 M+H). HPLC (100% purity, retention time 2.103 minutes-Method A); 1H NMR (400 MHz, DMSO-d6): 6 11.34 (br s, 1H), 10.66 (br s, 1H), 8.27 (s, 1H), 3.82 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.