Reference of 16078-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2 (0.01 mol), and ethyl-5-amino-1-phenyl-1Hpyrazole-4-carboxylate in 1,4-dioxane 10 ml containingthree drops of triethylamine was heated under reflux for 3 h.The reaction mixture was poured into crushed ice water, andacidified with dil. HCl. The solid obtained was recrystallizedfrom dioxane to give 17. White needles; yield 69%;mp. 130-131oC; IR (KBr) numax 3344, 3217 (2NH), 2927(CH-aliph.), 1658 (C=O), 1624 (C=N), 1384, 1157 cm-1(SO2); 1H NMR (DMSO-d6, 300 MHz,): delta = 1.23 (t, 3H,CH3), 4.47 (q, 2H, CH2), 5.67 (s, 2H, pyrazole-H), 6.47 (s,1H, pyrazole-H), 7.4-7.64 (m, 15H, Ar- H+ NH), 10.37,11.71 ppm (2s, 2H, 2NH, exchangeable with D2O); EIMSm/z 558 (M-29 (C2H5)), 73 (100); anal. calcd. ForC28H25N7O4 S2: C, 57.23; H, 4.29; N, 16.68. Found: C,57.40; H, 4.50; N, 16.90.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.