Electric Literature of 10010-93-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10010-93-2 as follows.
a) A mixture of potassium carbonate (922 mg, 6.67 mmol), 2-methyl-5-(trifluoromethyl)-1H-pyrazole (500 mg, 3.33 mmol) and ethyl 2-bromopropanoate (0.48 mL, 3.7 mmol) in dimethylformamide:tetrahydrofuran (3 mL:6 mL) was heated at 60 C. for 5 h with stirring. After cooling to room temperature, most of tetrahydrofuran was removed by gently blowing nitrogen over the reaction mixture. Ethyl acetate and water were added and the layers were separated. The aqueous layer was extracted twice more with ethyl acetate. The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo. The crude residue was purified by flash chromatography (SiO2, 10-20% ethyl acetate in hexanes) to afford the desired product (735 mg, 2.94 mmol, 88%).
According to the analysis of related databases, 10010-93-2, the application of this compound in the production field has become more and more popular.