Application of 478968-48-8, A common heterocyclic compound, 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0765] A mixture of ethyl 3-methoxy-1H-pyrazole-4-carboxylate (200 mg, 1.18 mmol), CuT (23 mg,0.12 mmol), L-proline (28 mg, 0.24 mmol), 5-bromo-2-(trifluoromethyl)pyrimidine (320 mg, 1.41mmol), and potassium carbonate (407 mg, 2.95 mmol) in N,N-dimethylformamide (6 mL) was stirredovernight at 100C under nitrogen. The solid was filtered out and the liquid was concentrated. Theresidue was purified by a silica gel colunm eluting with dichloromethane to afford the title compound(210 mg, 57%) as a light yellow solid. LCMS [M+H]317; ?H NMR (300 MHz, CDC13) 3 9.21 (s, 2H),8.40 (s, 1H), 4.39-4.32 (m, 2H), 4.12 (s, 3H), 1.38 (t, J= 7.2 Hz, 3H).
The synthetic route of 478968-48-8 has been constantly updated, and we look forward to future research findings.