Related Products of 85290-80-8,Some common heterocyclic compound, 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (480 mg, 3.1 mmol) in ethanol cooled to 0 C. was treated with a 1N aqueous sodium hydroxide solution (9.3 mL, 9.3 mmol). The reaction was stirred at 25 C. for 18 h. At this time, the reaction was concentrated in vacuo and then acidified to pH=2 with a 1N aqueous hydrochloric acid solution. The product was extracted into ethyl acetate (2*50 mL). The organics were washed with a saturated aqueous sodium chloride solution (1*25 mL), dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (293 mg, 74.6%) as a white solid: EI-HRMS m/e calcd for C5H6N2O2 (M+) 126.0429, found 126.0429.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-1H-pyrazole-4-carboxylate, its application will become more common.