Category: 85290-80-8

Adding a certain compound to certain chemical reactions, such as: 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85290-80-8, Application In Synthesis of Ethyl 1-methyl-1H-pyrazole-4-carboxylate

Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (300 mg, 1.95 mmol) in ethanol cooled to 0 C. was treated with a 1N aqueous sodium hydroxide solution. The reaction was then warmed to 25 C. and was stirred at 25 C. for 18 h. At this time, the reaction was concentrated in vacuo and acidified to pH=2 with a 1N aqueous hydrochloric acid solution. This solution was extracted with ethyl acetate (3*50 mL). The organics were washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (193 mg, 78.5%) as a white solid: LR-MS for C5H6N2O2 (M-H)+ at m/z=125.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dunten, Peter W.; Foley, Louise H.; Huby, Nicholas J.S.; Pietranico-Cole, Sherrie L.; Yun, Weiya; US2004/14766; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 85290-80-8,Some common heterocyclic compound, 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 1-methyl-1H-pyrazole-4-carboxylate (20.2 g, 131 mmol) and NaOH (6.3 g, 158 mmol) in 200 mL absolute ethanol was refluxed for 2 h and stirring was continued at RT for 18 h. After that, the solvent was removed in vacuo. The residue was dissolved in water. The aq solution was washed with ether and acidified with concentrated HCl. The solid was filtered, washed with water and air-dried to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.

The synthetic route of 85290-80-8 has been constantly updated, and we look forward to future research findings.

Related Products of 85290-80-8,Some common heterocyclic compound, 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (480 mg, 3.1 mmol) in ethanol cooled to 0 C. was treated with a 1N aqueous sodium hydroxide solution (9.3 mL, 9.3 mmol). The reaction was stirred at 25 C. for 18 h. At this time, the reaction was concentrated in vacuo and then acidified to pH=2 with a 1N aqueous hydrochloric acid solution. The product was extracted into ethyl acetate (2*50 mL). The organics were washed with a saturated aqueous sodium chloride solution (1*25 mL), dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (293 mg, 74.6%) as a white solid: EI-HRMS m/e calcd for C5H6N2O2 (M+) 126.0429, found 126.0429.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-1H-pyrazole-4-carboxylate, its application will become more common.

Application of 85290-80-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 85290-80-8 as follows.

Step 2 Preparation of 1-methyl-1H-pyrazole-4-carboxylic acid A solution of 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (300 mg, 1.95 mmol) in ethanol cooled to 0¡ã C. was treated with a 1N aqueous sodium hydroxide solution. The reaction was then warmed to 25¡ã C. and was stirred at 25¡ã C. for 18 h. At this time, the reaction was concentrated in vacuo and acidified to pH=2 with a 1N aqueous hydrochloric acid solution. This solution was extracted with ethyl acetate (3*50 mL). The organics were washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and dried in vacuo to afford 1-methyl-1H-pyrazole-4-carboxylic acid (193 mg, 78.5percent) as a white solid: LR-MS for C5H6N2O2 (M-H)+ at m/z=125.

According to the analysis of related databases, 85290-80-8, the application of this compound in the production field has become more and more popular.