Wang, Zhenyu published the artcileSwitching the Enantioselectivities in Michael Addition of Pyrazolin-5-Ones to Nitroolefins by Benzoylthiourea Organocatalysts, Application In Synthesis of 14580-22-4, the publication is ChemistrySelect (2017), 2(12), 3419-3422, database is CAplus.
A series of novel cinchona alkaloid derived benzoylthiourea organocatalysts, e.g., I was synthesized and applied as hydrogen bonding organocatalysts in the enantioselective Michael addition of pyrazolin-5-ones II (R1 = C6H5, 2-ClC6H4, 4-CH3C6H4, 4-F3CC6H4) to nitroolefins R2HC=CHNO2 (R2 = C6H5, 2-ClC6H4, 2-furyl, etc.). These organocatalysts promoted the Michael additions smoothly and gave the desired R or S enantiomers of the products flexibly in high yields with excellent enantioselectivities (up to 92% ee and 89% ee resp.) by the proper choice of organocatalysts.
ChemistrySelect published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H18O, Application In Synthesis of 14580-22-4.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics