Harris, Philip A. published the artcileDiscovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis, Category: pyrazoles-derivatives, the publication is ACS Medicinal Chemistry Letters (2013), 4(12), 1238-1243, database is CAplus and MEDLINE.
Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo-[2,3-b]-pyridines, and furo-[2,3-d]-pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our inhouse kinase focused sets. An exemplar from the furo-[2,3-d]-pyrimidine series showed a dose proportional response in protection from hypothermia in a mouse model of TNFα induced lethal shock.
ACS Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.
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https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics