On December 24, 2008, Sprott, Kevin; Talley, John Jeffrey; Pearson, James Philip; Milne, Todd G. published a patent.Formula: C9H7N3O2 The title of the patent was Indole derivatives as FAAH inhibitors and their preparation and use in the treatment of diseases. And the patent contained the following:
Indole derivatives of formula I that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives The compounds are substituted at least at the 3 position of the indole. Compounds of formula I wherein each V, W, X, Y, Z, J, K, L and M are independently N and C; each P1 – P6 are independently N and C; each Q1 – Q6 are independently N and C; A and A’ are independently OH, and (un)substituted C1-3 alkoxy; AA’ taken together to form =O, =NOH, and =NOMe, etc.; dashed bonds indicated single and double bonds; R2 is halo, OH, NO2, (un)substituted C1-5 alkyl, (un)substituted C1-5 alkoxy, etc.; each of R4 – R17 is absent when bonded to N; each one of R4 – R17 is H, halo, NO2, CN, CO2H, OH, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was tested for its FAAH inhibitory activity. From the assay, it was determined that compound II exhibited IC50 valued of < 1 μM. The experimental process involved the reaction of 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid(cas: 1014631-89-0).Formula: C9H7N3O2
The Article related to indole preparation faah inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C9H7N3O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics