Xu, Juan; Zhao, Xinyu; Kang, Congmin published an article in 2018, the title of the article was Improved synthesis of pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives.Product Details of 143803-93-4 And the article contains the following content:
Pyrazolo[1,5-a]pyridine-3-carboxylate derivatives were obtained from 1,3-dipolar cycloaddition reaction with Et propynoate and N-aminopyridine sulfate synthesized by the reactions of substituted pyridines and hydroxyamine-O-sulfonic acid. They were further treated with 30% NaOH aqueous solution to give corresponding substituted pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives In this method, N-aminopyridine sulfate was directly put into the next reaction, which eliminated the step of converting sulfate into iodine salt in the traditional method and solved the problem that the iodine salt was difficult to precipitate N-aminopyridine sulfate and Et propynoate were dissolved in water and N,N-dimethylformamide, resp., and then mixed to increase the solubility of reactants. Six compounds (4a∼4f) were successfully synthesized with yields of 88%∼93%. The method is mild and easy to process and has low cost as a new process for mass production The experimental process involved the reaction of 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 143803-93-4).Product Details of 143803-93-4
The Article related to pyrazolopyridine carboxylic acid derivative synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Product Details of 143803-93-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics