On January 16, 2020, Brace, Gareth Neil; Brookings, Daniel Christopher; Foulkes, Gregory; Lecomte, Fabien Claude published a patent.Name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid The title of the patent was Spirocyclic indane analogs as IL-17 modulators and their preparation. And the patent contained the following:
A series of substituted spirocyclic indane derivatives of formula I, and analogs thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. Compounds of formula I wherein ring A is C3-9 cycloalkyl, C3-7 heterocycloalkyl and C4-9 heterobicycloalkyl; B is CR2 and N; D is CR3 and N; E is CR4 and N; XY is OCY1Y2, NHSO2 and derivatives, CO2, etc.; R1 is (un)substituted C1-6 alkyl, (un)substituted C3-9 cycloalkyl, (un)substituted aryl, (un)substituted heteroaryl, etc.; R2, R3 and R4 H, halo, CN, C1-6 alkyl, etc.; Y1 is H, halo, CN, CF3, etc.; Y2 is H, halo and C1-6 alkyl; and N-oxides as pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of lithium 2-cyclooctyl-2-(3-methylisoxazole-4-carboxamido)acetate with spiro[indene-1,4′-oxane]-5-amine. The invention compounds were evaluated for their IL-17 modulatory activity (some data given). The experimental process involved the reaction of 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid(cas: 1340372-11-3).Name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid
The Article related to spirocyclic indane preparation il17 modulator, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylic acid
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics