Harju, Kirsi; Kylaenlahti, Irene; Paananen, Timo; Polamo, Mika; Nielsen, John; Yli-Kauhaluoma, Jari published an article in Journal of Combinatorial Chemistry. The title of the article was 《Solid-Phase Synthesis of Pyrazolopyridines from Polymer-Bound Alkyne and Azomethine Imines》.Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid The author mentioned the following in the article:
Study was made of the 1,3-dipolar cycloaddition of polymer-bound alkynes [I; R = Me, Ph, CO2H; P = polymer residue of 4-(bromomethyl)phenoxymethyl polystyrene cross-linked with 1% divinylbenzene (bromo-Wang resin)] to azomethine imines generated in situ from N-aminopyridine iodides, i.e. 1-amino-2-methylpyridinium iodide, 2-aminoisoquinolinium iodide, 1-amino-4-methylquinolinium iodide, 1-amino-4-methoxycarbonylpyridinium iodide, 1-amino-3-methylpyridinium iodide, 1-amino-3-(hydroxymethyl)pyridinium iodide and 1-aminoquinolinium iodide. Aromatization of the cycloadducts gives polymer-bound pyrazolopyridines (II; R1 = Q-Q11; R2 = H, Me) that can be released from the resin as carboxylic acids (R1-CO2H) with trifluoroacetic acid or as Me esters (R1-CO2Me) with sodium methoxide. After reading the article, we found that the author used 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid)
2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics