Fuse, Shinichiro; Suzuki, Kensuke; Kuchimaru, Takahiro; Kadonosono, Tetsuya; Ueda, Hiroki; Sato, Shinichi; Kizaka-Kondoh, Shinae; Nakamura, Hiroyuki published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity》.Name: 1-Methylpyrazole The author mentioned the following in the article:
In this study, indeno[2,1-c]pyrazolones, compounds I [Y = C, N; R1 = H, Me; R2 = H, Me, Ph, etc] were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4-5 steps from com. available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound I [Y = C, R1 = H, R2 = 4-MeC6H4] showed a higher level compared with that of known inhibitor, YC-1. The compound I [Y = C, R1 = H, R2 = 4-MeC6H4] suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Name: 1-Methylpyrazole)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Name: 1-Methylpyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics