Category: 80537-07-1

In 2016,Advanced Synthesis & Catalysis included an article by Alam, Khyarul; Kim, Seong Min; Kim, Do Joong; Park, Jin Kyoon. Application of 80537-07-1. The article was titled 《Development of Structurally Diverse N-Heterocyclic Carbene Ligands via Palladium-Copper-Catalyzed Decarboxylative Arylation of Pyrazolo[1,5-a]pyridine-3-carboxylic Acid》. The information in the text is summarized as follows:

A series of fused non-classical normal N-heterocyclic carbenes, Pyrpy-NHC precursors derived from pyrazolo[1,5-a]pyridines, has been prepared using palladium-copper-catalyzed decarboxylative arylation of pyrazolo[1,5-a]pyridine-3-carboxylic acid. Air-stable palladium and rhodium complexes of these ligands have been synthesized via mild transmetalation of Ag-Pyrpy-NHC. The structural properties of Rh(Pyrpy-NHC)(COD)Cl complexes were determined via X-ray anal. The measurement of the CO stretching frequencies of dicarbonyl Rh-Pyrpy-NHC complexes revealed that the electron donating strength of Pyrpy-NHC could be tuned by varying the substituents of the aryl group. A catalytic study of the Pd-Pyrpy-NHC complexes revealed promising activity in the Suzuki-Miyaura reaction under ambient atm. conditions. The experimental part of the paper was very detailed, including the reaction process of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1Application of 80537-07-1)

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Application of 80537-07-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Harju, Kirsi; Kylaenlahti, Irene; Paananen, Timo; Polamo, Mika; Nielsen, John; Yli-Kauhaluoma, Jari published an article in Journal of Combinatorial Chemistry. The title of the article was 《Solid-Phase Synthesis of Pyrazolopyridines from Polymer-Bound Alkyne and Azomethine Imines》.Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid The author mentioned the following in the article:

Study was made of the 1,3-dipolar cycloaddition of polymer-bound alkynes [I; R = Me, Ph, CO2H; P = polymer residue of 4-(bromomethyl)phenoxymethyl polystyrene cross-linked with 1% divinylbenzene (bromo-Wang resin)] to azomethine imines generated in situ from N-aminopyridine iodides, i.e. 1-amino-2-methylpyridinium iodide, 2-aminoisoquinolinium iodide, 1-amino-4-methylquinolinium iodide, 1-amino-4-methoxycarbonylpyridinium iodide, 1-amino-3-methylpyridinium iodide, 1-amino-3-(hydroxymethyl)pyridinium iodide and 1-aminoquinolinium iodide. Aromatization of the cycloadducts gives polymer-bound pyrazolopyridines (II; R1 = Q-Q11; R2 = H, Me) that can be released from the resin as carboxylic acids (R1-CO2H) with trifluoroacetic acid or as Me esters (R1-CO2Me) with sodium methoxide. After reading the article, we found that the author used 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid)

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Name: 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Safety of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acidOn October 31, 1981 ,《1,3-Dipolar addition of pyridine N-imine to acetylenes and the use of carbon-13 NMR in several structural assignments》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Anderson, Paul L.; Hasak, James P.; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.. The article conveys some information:

Addition of pyridine N-imine to EtO2CCCR (R = H, Me, Ph) or MeO2CCCCO2Me gave I (same R) or II, resp. Several of the 3-azapyrrocoline esters obtained were further converted into acids, amides and hydrazides. The experimental part of the paper was very detailed, including the reaction process of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1Safety of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid)

2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 80537-07-1) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Safety of 2-Phenylpyrazolo[1,5-a]pyridine-3-carboxylic acid

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics