In 1988,Tserunyan, V. V.; Asratyan, G. V.; Darbinyan, E. G. published 《Intramolecular hydrogen bond in 1-vinyl-5-pyrazolecarboxylic acid esters》.Khimiya Geterotsiklicheskikh Soedinenii published the findings.Computed Properties of C5H6N2O2 The information in the text is summarized as follows:
Pyrazolecarboxylates I (R = Me, Et, CHMe2, Bu; R1 = H) reacted with vinyl acetate in the presence of Hg(OAc)2 to give I (same R; R1 = vinyl) and their isomers (II). Intramol. H bonding between the α proton of the vinyl group and the carbonyl O was detected in II by NMR. After reading the article, we found that the author used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)
Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C5H6N2O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics