Kuduk, Scott D.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 20154-03-4

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Synthetic Route of C4H3F3N2

In 2010,Kuduk, Scott D.; Di Marco, Christina N.; Cofre, Victoria; Pitts, Daniel R.; Ray, William J.; Ma, Lei; Wittmann, Marion; Veng, Lone; Seager, Matthew A.; Koeplinger, Kenneth; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T. published 《N-Heterocyclic derived M1 positive allosteric modulators》.Bioorganic & Medicinal Chemistry Letters published the findings.Synthetic Route of C4H3F3N2 The information in the text is summarized as follows:

Replacement of a Ph ring with N-linked heterocycles in a series of quinolone carboxylic acid M1 pos. allosteric modulators was investigated. In particular, the pyrazole derivative I exhibited improvements in potency, free fraction, and CNS exposure. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Synthetic Route of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics