Day: April 27, 2021

Electric Literature of 37622-90-5, The chemical industry reduces the impact on the environment during synthesis 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, I believe this compound will play a more active role in future production and life.

Polymer-supported triphenylphospine (3.0mmol/g, 3 equiv, 1.0g) was swollen inTH F /dichloromethane (1: 1, 1 OOmls) under a nitrogen atmosphere. Ethyl 1 H-pyrazole-4-carboxylate (500mg, 3.57mmol) and 4-(chloromethyl)benzyl alcohol (671mg, 4.28mmol) were30 added followed by a solution of diisopropyl azodicarboxylate (1.08g, 5.35mmol) inTHF/dichloromethane (1: 1, 1 Omls) over a period of 30m ins. The reaction mixture was stirred at room temperature for 18 hours, the mixture was filtered through celite and the resin waswashed with 3 cycles of dichloromethane/methanol (1Smls). The combined filtrates wereevaporated in vacuo and triturated with ethanol to give a white solid identified as 1-(4-chloromethyl-benzyl)-1 H-pyrazole-4-carboxylic acid ethyl ester (7 41 mg, 2 .66m mol, 7S%).S [M+Hr = 279.0S

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-pyrazolecarboxylate, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Methyl-1H-pyrazol-3-amine

A solution of 1-methyl-1H-pyrazol-3-ylamine (0.92 g, 9.5 mmol) in benzene (4.8 mL) was treated with hexane-2,5-dione (1.34 mL, 11.4 mmol) and para-toluenesulfonic acid (182 mg, 0.95 mmol) and was heated to 115° C. under Dean-Stark conditions for 4 h. After this time, the reaction was cooled to 25° C., concentrated in vacuo and dried under high vacuum overnight. The resulting residue was dissolved in methylene chloride (100 mL) and was washed with water (1.x.150 mL), dried over sodium sulfate, filtered and concentrated in vacuo. Silica gel column chromatography (ISCO, 80 g, 1:4 ethyl acetate/hexanes) afforded 3-(2,5-dimethyl-pyrrol-1-yl)-1-methyl-1H-pyrazole (1.57 g, 94percent) as a green oil; ES+-HRMS m/e calcd for C10H13N3 [M+H+] 176.1182, found 176.1182.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1904-31-0, its application will become more common.

Application of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1.4: 5-Amino-1-(4-bromo-phenyl)-1H-pyrazole-4-carboxylic acid amide5-Amino-1-(4-bromo-phenyl)-1 H-pyrazole-4-carbonitrile (18.3 g, 69.8 mmol) is slowly added to 93 ml concentrated sulfuric acid (1680 mmol) to keep the temperature between 10-15 C. After the complete addition of the starting material, the reaction mixture is stirred for one hour. Afterwards, the mixture is poured on ice/water and the pH is adjusted to pH 8. The formed precipitate is isolated by filtration and is dried at the high vacuum pump, yielding the title compound. HPLC: tR = 7.91 min; MS-ES+: (M+H)+ = 282

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 2644-93-1

(n-BuLi (1.02 mL, 2.5 M in hexane, 2.55 mmol) was added drop-wise to a -70 C. solution consisting of 3-(benzyloxy)-6-bromo-4-chloro-2-methoxy-8-methylquinoline (1.0 g, 2.5 mmol, Intermediate 89: step f) and THF (50 mL). The resultant reaction mixture was stirred at -70 C. for 20 minutes and then treated with a solution of 1,3,5-trimethyl-1H-pyrazole-4-carbaldehyde (352 mg, 2.55 mmol) and THF (15 mL) at -70 C. The resulting mixture was stirred at room temperature for 20 minutes before quenching with saturated aqueous NH4Cl (20 mL) and extracting with dichloromethane:methanol (5:1, 50 mL*10). The combined organic extracts were dried over Na2SO4, filtered and concentrated to dryness under reduced pressure to give the crude product, which was purified by FCC (silica gel, eluent: petroleum ether:ethyl acetate=5:1 to 1:1) to afford the title compound.

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.

Related Products of 96799-02-9, The chemical industry reduces the impact on the environment during synthesis 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.

3- Ethynylaniline (146 mg, 1.25 mmol) and DIPEA (0. 22 mL, 1.25 mmol) were added to a solution of cyanuric chloride (230 mg, 1.25 mmol) in THF (16 mL) at 0 0C. The reaction mixture was stirred at 0 C to room temperature for 2 hours. 3-amino-5-(2-furyl) pyrazole (187 mg, 1.25 mmol) and DIPEA (0.22 mL, 1.25 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1 -methylpiperazine (0.28 mL, 2.50 mmol) and DIPEA (0.44 mL, 2.50 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 0C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column and eluted with 0- 5 % MeOH/DCM which afforded compound 36 as light brown solid (130 mg, 24%). 1H NMR (400 MHz, DMSO-d6) delta 12.75 (bs, IH, NH), 10.19-9.44 (m, 2H, NH), 7.83- 6.06 (m, 8H, Ar- H), 4.14-4.04 (m, IH, CH), 3.77 (s, 4H, 2CH2), 2.37 (s, 4H, 2CH2), 2.22 (s, 3H, CH3); ESI- MS: calculated for (C23H23N9O) 441 , found 442 [M+H]+. HPLC: retention time: 15.31 min. purity: 95%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Furan-2-yl)-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 345637-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-[4-(5-{2-[(Methylsulphonyl)ammonio]phenyl}-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidinium dichloride (201 mg), [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (104 mg) and triethylamine (51 mg) are dissolved in dichloromethane (10 ml) and the mixture is stirred for 10 min. The mixture is stirred for a further 10 min, before bromotris(pyrrolidino)phosphonium hexafluorophosphate (254 mg) is added. The reaction mixture is stirred at room temperature for 2 hours. After removal of the solvent under reduced pressure, the residue is purified by chromatography. This gives N-(2-{3-[2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-O-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl)methanesulphonamide (107 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., name: 4-Nitro-1H-pyrazole-3-carboxylic acid

[00842] Example 209: 4- [ (Aminocarbonyl) amino]-l- (3-chloro-4- methoxyphenyl)-1 H-pyrazole-3-carboxamide; [00844] Step 1: Preparation of ethyl 4-nitro-1 H-pyrazole-3-carboxylate [00846] 4-Nitro-1 H-pyrazole-3-carboxylic acid (2 g, 12.73 mmol ; Aldrich) was refluxed in absolute ethanol (25 mL) containing trace sulfuric acid (0. 2. mol) for 5 h. The reaction was evaporated and partitioned between EtOAc and 5% NaHCO3. The EtOAc layer was separated, dried over MgSO4 and filtered. The EtOAc was removed to give a white solid.’H. NMR (300 MHz, DMSO-d6) : 5 1.28 (t, J=7 Hz, 3 H), 4. 34 (q, J=7 Hz, 2 H), 8.91 (s, 1 H), 14.39 (br s, 1 H); MS (ESI+) for CH N 186. 1 (M+H) +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide

General procedure: To a solution of aromatic aldehydes 8 (1.0 mmol) in acetonitrile, 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 10 (1.0 mmol) and InCl3 (10 mol%) were added at room temparature and the reaction mixture was stirred till the completion of the starting materials (indicated by TLC). The solvent was evoparated and the crude product was triturated with 10% diethyl ether in hexane to obtain the pure product. The product was identified by 1H NMR, 13 C NMR and Mass.

The synthetic route of 139756-02-8 has been constantly updated, and we look forward to future research findings.

Application of 14531-55-6, The chemical industry reduces the impact on the environment during synthesis 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 3,5-dimethyl-4-nitro-1 H-pyrazole (see international patent application WO 2003057673) (3.982g, 28.22 mmol), iodobenzene (11.3 mL, 101.4 mmol), K2CO3 (8.19 g, 59.26 mmol), CuI (268.8 mg, 1.41 mmol), andtrans-N,N?-di-methylcyclohexane-1,2-diamine (890 mL, 5.63 mmol) were heated to 180 C in a microwave reactor for 4h under argon. The reaction mixture was cooled to room temperature, diluted with EtOAc (250 mL), filtered throughcelite, and the product was purified by column chromatography (30?40?75% EtOAc in petroleum ether) to give 4.428g (72%) of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C4H3F3N2

[00554] Intermediate 55a: ethyl 2-[3-(trifluoromethyl)pyrazol-1-yI]acetate[00555] A solution of 3-(trifluoromethyl)-1 H-pyrazole (75mg, 0.SSmmol) and potassium carbonate (228mg, 1 .6Smmol) were left to stir in MeCN (2mL) for 30 minutes before the addition of ethyl bromoacetate (0.O9mL, 0.83mmol). The reaction mixture was then heated to 60 °C and left to stir for 2 hours. The reaction mixture was quenched by the addition of water (2OmL) and extractedusing EtOAc (3 x 2OmL). The organic layers were combined, dried over Na2504, filtered andconcentrated in vacuo to give ethyl 2-[3-(trifluoromethyl)pyrazol-1-yl]acetate (1 20mg, 0.SSmmol,100percent yield) as a yellow oil which was used in the next step without further purification.1H NMR (CDCI3,400MHz) O/ppm: 7.55 (1H, dd, J= 2.3Hz, 0.9Hz), 6.59 (1H, d, J= 2.2Hz), 4.96 (2H,5), 4.25 (2H, q, J= 7.1Hz), 1.29 (3H, t, J= 7.1Hz).MS Method 2: RT: 1.58 mi m/z 223.1 [M+H]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20154-03-4, its application will become more common.