Electric Literature of 345637-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
4-[4-(5-{2-[(Methylsulphonyl)ammonio]phenyl}-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidinium dichloride (201 mg), [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (104 mg) and triethylamine (51 mg) are dissolved in dichloromethane (10 ml) and the mixture is stirred for 10 min. The mixture is stirred for a further 10 min, before bromotris(pyrrolidino)phosphonium hexafluorophosphate (254 mg) is added. The reaction mixture is stirred at room temperature for 2 hours. After removal of the solvent under reduced pressure, the residue is purified by chromatography. This gives N-(2-{3-[2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-O-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl)methanesulphonamide (107 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.