Month: April 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

d) 2-Methyl-5 – [5 -methyl-3 -(tetrahydro-pyran-4-yl)-isoxazo 1-4-ylmethoxy] -2H-pyrazo le-3 -car- boxylic acid methyl esterTo a stirred solution of 5 -hydro xy-2-methyl-2H-pyrazo le-3 -carboxylic acid methyl ester (4.68 g, 30 mmol) and [5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-yl]-methanol (5.92 g, 30 mmol) in THF (400 mL) at 5 0C under argon was added triphenylphosphine (10.6 g, 39 mmol), then diisopropyl azodicarboxylate (8.23 mL, 39 mmol) was added dropwise. The reaction mixture was warmed to room temperature overnight. The reaction mixture was then extracted with ethyl acetate and the organic extract washed with water, dried over sodium sulphate, filtered and evaporated. Purification by chromatography (silica, heptane:ethyl acetate = 1 :1) afforded the title compound (7.26 g, 85%) as a white solid. MS: m/e = 336.2 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 14521-80-3, name is 3-Bromo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14521-80-3, HPLC of Formula: C3H3BrN2

Step A: Preparation of methyl N-[[5-(3-bromo- lH-pyrazol- 1 -yl)-2- methylphenyljmethyl] carbamate Methyl N-[(2-methyl-5-iodophenyl)methyl]carbamate (i.e. the product of Example 3, Step C) (5.00 g, 16.4 mmol), 3-bromopyrazole (3.11 g, 21.3 mmol), potassium carbonate (5.65 g, 41.0 mmol), and copper (I) iodide (623 mg, 3.28 mmol) were combined in toluene (16 mL) and N,N’-dimethylformamide (16 mL). A stream of nitrogen gas was bubbled into the mixture for 30 min., N,1ST -dimethyl- 1 ,2-cyclohexanediamine (1.0 mL, 6.6 mmol) was added and a stream of nitrogen gas was bubbled through the mixture for an additional 30 min. The nitrogen line was then raised above the reaction mixture and the mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered through a fritted- glass funnel and then concentrated under vacuum. The resultant residue was purified by medium pressure liquid chromatography using a gradient of 10 to 50% ethyl acetate in hexanes to provide the title compound (4.35 g) as an off- white solid. in NMR (500 MHz, CDC13) delta 7.76 (d, J=2.5 Hz, 1 H), 7.55 (d, J=2.0 Hz, 1 H), 7.42 (dd, J=8.1, 2.0 Hz, 1 H), 7.23 (d, J=8.2 Hz, 1 H), 6.45 (d, J=2.6 Hz, 1 H), 5.00 (bs, 1 H), 4.40 (d, J=5.7 Hz, 2 H), 3.71 (s, 3 H), 2.34 (s, 3 H).

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Application of 3469-69-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-69-0, name is 4-Iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of NaH (0.463 g, 15.47 mmol, 80% NaH/mineral oil) in DMF (100 mL) was added 4-iodo-pyrazole (1.0 g, 5.16 mmol) at 0 C under N2 atmosphere, the mixture was stirred at 0 C for 30 minutes, then iodomethane (0.64 mL, 10.31 mmol, d = 2.28) was added. The resulted mixture was warmed to rt and stirred overnight, then quenched with brine (100 mL), and concentrated in vacuo. The residue was diluted with EtOAc (200 mL) and washed with water (100 mL). The separated organic phase was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 2/1) to give the title compound as a light yellowish solid (490 mg, 45%). NMR (400 MHz, CDCb): delta 7.48 (s, 1H), 7.40 (s, 1H), 3.91 (s, 3H).

The synthetic route of 4-Iodopyrazole has been constantly updated, and we look forward to future research findings.

Reference of 14521-81-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14521-81-4, name is 3-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 4, 6-dichloro-N-(4, 4-difluorocyclohexyl) pyrimidin-2-amine (1 g, 3.54 mmol) in acetonitrile (10 mL) was added 3-fluoro pyrazole (0.36 g, 4.25 mmol) and cesium carbonate (2.30 g, 7.089 mmol). The reaction mixture was heated at 80 C for 8h. The reaction mixture was filtered and the filtrate was concentrated to afford crude product and which was purified by column chromatography (60-120 mesh) using 22% ethyl acetate in pet ether as solvent to afford 4, 6-dichloro-N-(4, 4- difluorocyclohexyl) pyrimidin-2-amine [Bj as an off-white solid (4 g, 32%). MS (M, M+2)=282.0, 284.1.

The chemical industry reduces the impact on the environment during synthesis 3-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

106368-32-5, name is 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile

A MIXTURE OF 5-AMINO-1- (4-METHANESULFONYL-PHENYL)-LH-PYRAZOLE-4-CARBONITRILE (540 mg), formic acid (10 mL) and 1 mL H2O was refluxed overnight at 102’C. After cooling to room temperature, a white precipitate was observed. The mixture was diluted with H20 (10 mL), filtered through a funnel and washed thoroughly with H20, CH30H, and diethyl ether. The white solid was collected and dried under vacuum to give a crude product (300 mg, 50% YIELD). H NMR (DMSO-D6, 4. 00 MHZ) 5 3. 26 (s, 3H), 8. 12 (d, 2H), 8. 29 (s, 1H), 8. 42 (d, 2H), 8. 44 (d, 1H), 12. 61 (s, 1H). LCMS : calculated C12HoN403S 290. 05, observed 291. 2 (MH+).

The synthetic route of 106368-32-5 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H2BrN3

was prepared: to a solution of Bis-CFhCI PF1022a in acetonitrile (4.8 ml_, 0.02M) was 4-bromo-1 H-pyrazole-3-carbonitrile added (66 mg, 0.38 mmol), potassium bicarbonate (38 mg, 0.38 mmol) and potassium iodide (95 mg, 0.57 mmol). The mixture was heated to 50C for 48 hours. After cooling to room temperature, the solvent was removed under reduced pressure and the residue partitioned between water and DCM. The organics were separated, dried over MgS04 and evaporated. The crude material was purified by reverse phase HPLC to give the title product as a white solid (46 mg).

The synthetic route of 4-Bromo-1H-pyrazole-5-carbonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 92933-47-6, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3 N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)-3-metbyipyrrolidin-3-yJ)cyclopropanecarboxamideTo a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (431 mg, 2.79 mmol) in DMF (6 mL) were added HATU (1.38 g, 3.63 mmol) and DIEA (1.85 mL, 11.18 mmol) and then stirred at room temperature for 5 minutes before the addition of N-(3 -methylpyrrolidin-3-yl)cyclopropane carboxamide hydrochloride (572 mg, 2.79 mmol) was added. The resulting mixture was stirred at room temperature for 16 hrs. The reaction mixture was filtered and the crude product was purifiedby preparative HPLC (Gemini C18, 150 x 25 mm xlO jam, 26-56% MeCN/H20) to give the desiredproduct (210 mg, 25% yield) as white solid. ?H NMR (400 MHz, DMSO-d6) 6 8.09 (s, IH), 6.41(s, IH), 4.17 – 4.14 (m, 0.SH), 3.88-3.72 (m, 2H), 3.55 -3.52 (m, 1H), 3.38 – 3.35 (m, 0.SH), 2,96-2.93 (m, IH), 2,31 -2.19 (m, 1H), 1.88- 1.72 (m, IH), 1.56- 1.53 (m, 111), 1.38 (s, 3H), 1.22(d, J 7.2 Hz, 6H), 0.63 -0.57 (m, 4H). LCMS (ESI) mlz: 305,1 [M+HJ, RT 0.904 mm(LCMS Method E).

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H10N4O4S

A solution of 4, 5-DIAMINO-1-METHYLPYRAZOLE sulfate (158 g) in water (1.1 L) was neutralized to pH 6.9 with 4N aqueous sodium hydroxide solution, and dioxane (474 ml) was added to this solution. To the resulting mixture was added dropwise phenyl chloroformate (124 g) maintaining pH of the mixture at 6.9 with 4N aqueous sodium hydroxide solution at a temperature below 10C. The reaction mixture was stirred for 1 hour. The precipitated solid was collected by filtration and dried to give 5-AMINO-1-METHYL-4-PHENOXYCARBONYLAMINOPYRAZOLE (155 G). 1H-NMR (DMSO-d6) 8 3.52 (3H, s), 5.00 (2H, brs), 7.10-7. 50 (6H, m), 8.93 (1H, brs)

According to the analysis of related databases, 20055-01-0, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 26308-42-9

General procedure: Pyrazole acid 9a-k (3 mmol) and thionyl chloride (7.5 mmol)were successively added to 20 mL 1,2-dichloroethane, the mixturewere stirred under reflux for 3 h and then concentrated underreduced pressure, the crude products were added in drops into asolution of 5?a-f (5a-h) (3 mmol) and trimethylamine (6 mmol) inTHF (15 mL).The reaction mixturewas stirred under the 0 C for thenight. After reaction the mixture was poured in Na2CO3 solutionand aqueous phase was extracted with ethyl acetate (2 20 mL).The combined organic phase was washed with saturated salt water(2 20 mL), dried over anhydrous Na2SO4, and concentrated underreduced pressure and the residue was purified by silica gel columnchromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 26308-42-9, its application will become more common.