Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate
d) 2-Methyl-5 – [5 -methyl-3 -(tetrahydro-pyran-4-yl)-isoxazo 1-4-ylmethoxy] -2H-pyrazo le-3 -car- boxylic acid methyl esterTo a stirred solution of 5 -hydro xy-2-methyl-2H-pyrazo le-3 -carboxylic acid methyl ester (4.68 g, 30 mmol) and [5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-yl]-methanol (5.92 g, 30 mmol) in THF (400 mL) at 5 0C under argon was added triphenylphosphine (10.6 g, 39 mmol), then diisopropyl azodicarboxylate (8.23 mL, 39 mmol) was added dropwise. The reaction mixture was warmed to room temperature overnight. The reaction mixture was then extracted with ethyl acetate and the organic extract washed with water, dried over sodium sulphate, filtered and evaporated. Purification by chromatography (silica, heptane:ethyl acetate = 1 :1) afforded the title compound (7.26 g, 85%) as a white solid. MS: m/e = 336.2 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.