Category: 288246-16-2

These common heterocyclic compound, 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H2BrN3

was prepared: to a solution of Bis-CFhCI PF1022a in acetonitrile (4.8 ml_, 0.02M) was 4-bromo-1 H-pyrazole-3-carbonitrile added (66 mg, 0.38 mmol), potassium bicarbonate (38 mg, 0.38 mmol) and potassium iodide (95 mg, 0.57 mmol). The mixture was heated to 50C for 48 hours. After cooling to room temperature, the solvent was removed under reduced pressure and the residue partitioned between water and DCM. The organics were separated, dried over MgS04 and evaporated. The crude material was purified by reverse phase HPLC to give the title product as a white solid (46 mg).

The synthetic route of 4-Bromo-1H-pyrazole-5-carbonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 288246-16-2, name is 4-Bromo-1H-pyrazole-5-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288246-16-2, HPLC of Formula: C4H2BrN3

To a solution of 4-bromo-3-cyano-lH-pyrazole 49 (172 mg, 1 mmol) in pyridine (3 mL) was added 2,5-difluorophenyl boronic acid (237 mg, 1.5 mmol), and 4A molecular sieves. The mixture was stirred for 72 h at room temperature. The reaction was worked-up with saturated NaHC0 and EtOAc extraction. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over a2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 50 (70 mg, 25%) as a blue wax.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-pyrazole-5-carbonitrile, other downstream synthetic routes, hurry up and to see.