Application of 3469-69-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-69-0, name is 4-Iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of NaH (0.463 g, 15.47 mmol, 80% NaH/mineral oil) in DMF (100 mL) was added 4-iodo-pyrazole (1.0 g, 5.16 mmol) at 0 C under N2 atmosphere, the mixture was stirred at 0 C for 30 minutes, then iodomethane (0.64 mL, 10.31 mmol, d = 2.28) was added. The resulted mixture was warmed to rt and stirred overnight, then quenched with brine (100 mL), and concentrated in vacuo. The residue was diluted with EtOAc (200 mL) and washed with water (100 mL). The separated organic phase was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 2/1) to give the title compound as a light yellowish solid (490 mg, 45%). NMR (400 MHz, CDCb): delta 7.48 (s, 1H), 7.40 (s, 1H), 3.91 (s, 3H).
The synthetic route of 4-Iodopyrazole has been constantly updated, and we look forward to future research findings.