Month: March 2021

Electric Literature of 13808-64-5, These common heterocyclic compound, 13808-64-5, name is 4-Bromo-3-methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4554-{7-Methanesulfonyl-5- [(S)-oxan-4-yl(phenyl)methylj -5H-pyrido [3,2-bj indol-3-yl}-3-methyl- 1H-pyrazole (S)-(7-(Methylsulfonyl)-5 -(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H- pyrido [3 ,2-b]indol-3 -yl)boronic acid (20.0 mg, 0.0430 mmol) and 4-bromo-3 -methyl-i Hpyrazole (13.9 mg, 0.0860 mmol) were dissolved in in 1.5 mL of dioxane and and 0.2 mLof water. To this was added potassium carbonate (17.9 mg, 0.129 mmol) and PdC12(dppf)-CH2C12 adduct (2.46 mg, 3.02 .imol), and argon was bubbled in while sonicating for 5 mm. The vial was capped, heated at 100 C for 50 mm, and filtered. The crude material was purified via preparative LC/MS (Preparative HPLC Method 1) with the following modifications: Gradient 10-50% B over 40 mm. Fractions containing thedesired product were combined and dried via centrifugal evaporation. The yield of the product was 1.20 mg, and its estimated purity by LCMS analysis was 96%. Two analytical LC/MS injections were used to determine the final purity Injection 1: LC/MS Method 3, HPLC RT = 1.83 mm. Injection 2: LC/MS Method 4, HPLC RT = 2.37 mm. ?H NMR (500MHz, DMSO-d6) oe 8.69 (s, 2H), 8.42 (d, J=8.4 Hz, 1H), 8.27 (br. s., 1H),8.01 (s, 1H), 7.82 (d, J=8.4 Hz, 1H), 7.67 (d, J=7.7 Hz, 2H), 7.36 (t, J=7.5 Hz, 2H), 7.27 (t, J=7.3 Hz, 1H), 5.99 (d, J=i 1.0 Hz, 1H), 3.90 (s, 2H), 3.72 (d, J=9.9 Hz, 2H), 3.60 (br. s., 2H), 3.52 (t,J=ii.2 Hz, 3H), 3.27 (t,J=ii.6 Hz, 1H), 2.43 (s, 3H), 1.85-1.73 (m, 1H), 1.72-1.58 (m, 1H), 1.46-1.27 (m, 1H), 0.89 (d,J=12.i Hz, 1H).

The synthetic route of 13808-64-5 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Nitro-1H-pyrazole-3-carboxylic acid

Step 1. 4-Nitro-lH-pyrazole-3-carboxylic acid ethyl ester; Thionyl chloride (2.90 ml, 39.8 mmol) was slowly added to a mixture of 4-nitro-3- pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in EtOH (100 ml) at ambient temperature and the mixture stirred for 48 hours. The mixture was reduced in vacuo and dried through azeotrope with toluene to afford 4-nitro-lH-pyrazole-3- carboxylic acid ethyl ester as a white solid (6.42 g, 96%). (1H NMR (400 MHz, DMSO-d6) delta 14.4 (s, IH), 9.0 (s, IH), 4.4 (q, 2H), 1.3 (t, 3H)).

The synthetic route of 4-Nitro-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C4H4N2O

A suspension of 1H-pyrazole-4-carbaldehyde (1.00 g, 10.41 mmol) in DCM (30 mL) was stirred under nitrogen. Triethylamine (1.45 mL, 10.41 mmol) was added resulting in a solution. The reaction was cooled to 0 oC with a cooling bath and benzyl carbonochloridate (1.49 mL, 10.41 mmol) was added as dropwise over 5 min maintaining the internal temperature below 10 oC. The reaction was allowed to stir at 4 oC with a cooling bath for 1 h. An aqueous 1M solution of hydrochloric acid (30 mL) was added cautiously. The layers were separated and the aqueous portion was extracted with DCM (2 x 30 mL). The combined organic extracts were washed with water (20 mL) and brine (20 mL). The combined organic extracts were passed through a phase separation cartridge and concentrated under reduced pressure. The resulting yellow residue was purified by flash silica chromatography eluting with a gradient of 0-50percent EtOAc in heptane. Product containing fractions were concentrated under reduced pressure to afford benzyl 4-formylpyrazole-1-carboxylate (1.78 g, 74percent) as a white solid. IR: 1736 (CO), 1674 (CO) cm-1; 1H NMR (400 MHz, CDCl3) 5.51 (s, 2H), 7.35 ? 7.47 (m, 3H), 7.47 ? 7.55 (m, 2H), 8.15 (s, 1H), 8.57 ? 8.71 (m, 1H), 9.96 (s, 1H); 13C NMR (400 MHz, CDCl3) 71.00, 126.11, 128.90, 129.02, 129.35, 133.62, 135.14, 142.86, 148.56, 183.49; HRMS [M+Na]+ measured 253.0578, C12H10O3N2 requires 253.0589.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 103626-03-5, name is Ethyl 1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103626-03-5, Product Details of 103626-03-5

To the mixture of ethyl 3-hydroxy-1-methyl-pyrazole-4-carboxylate (200.0 mg, 1.18 mmol) and 1,3-dioxolan-2-ylmethanol (159 mg, 1.53 mmol) in THF (5.0 mL) at room temperature was added tri-N-butylphospine (309 mg, 1.53 mmol) followed by diisopropyl azodicarboxylate (309 mg, 1.53 mmol) dropwise. The resulting mixture was stirred at room temperature for 3 hours and then heated at 70 C. for overnight. The reaction was cooled to room temperature, concentrated, purified by combiflash (12 g silica gel, 0-50% EtOAc/Hexanes). The desired fractions were concentrated to give the title compound. 1H NMR (400 MHz, Chloroform-d) delta 7.80 (s, 1H), 5.24 (t, J=3.9 Hz, 1H), 4.51 (d, J=3.9 Hz, 2H), 4.30 (q, J=7.1 Hz, 2H), 4.07-3.99 (m, 2H), 3.99-3.93 (m, 2H), 3.76 (s, 3H), 1.37 (t, J=7.1 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 146941-72-2, name is 4-Bromo-1-methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H6BrN3

A) To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (310 mg) and triethylamine (0.37 mL) in THF (8.8 mL) was added 4-chlorobutanoyl chloride (0.22 mL) under ice-cooling, and the mixture was stirred at 0 C. for 30 min. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (456 mg). MS (ESI+): [M+H]+280.0.

The synthetic route of 146941-72-2 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

1) 1-Methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole A mixture of 5-iodo-1-methyl-1H-pyrazole (8.00 g), 1-ethynyl-4-(trifluoromethyl)benzene (6.54 g), copper(I) iodide (110 mg), bis(triphenylphosphine)palladium(II) dichloride (1.35 g), triphenylphosphine (504 mg), triethylamine (8.00 mL) and dimethylformamide (70 mL) was stirred at 75 C. for 2 hours. Thereafter, the reaction solution was added to water, and the obtained mixture was then extracted with ethyl acetate. The organic layer was successively washed with water and a saturated saline, and was then dried over anhydrous magnesium sulfate, followed by vacuum concentration. The residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=85:15 to 75:25), so as to obtain the title compound (7.74 g) in the form of a yellow solid. 1H NMR (200 MHz, CHLOROFORM-d) delta ppm 4.01 (s, 3H) 6.53 (d, J=2.20 Hz, 1H) 7.49 (d, J=2.20 Hz, 1H) 7.64 (s, 4H); MS (ESI pos.) m/z 251 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34091-51-5.

Related Products of 16078-71-0, The chemical industry reduces the impact on the environment during synthesis 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

In the with the condensation tube, thermometer of 250 ml three-neck bottle in, adding […] ethyl acetate (62.1 mmol), phenyl hydrazine (93.2 mmol), ethanol (50 ml), heated to 80 C, reaction 24 h, TLC detection after the reaction, to the room temperature, the solvent is distilled under reduced pressure, the remaining solid without purification directly dissolved in absolute ethanol (200 ml), 80% hydrazine hydrate solution (100 mmol) is slowly added in the reaction solution, heating to reflux 2 hours, TLC detection reaction is over, the system to the room temperature, filtered, washing the solid with ethanol, dry and obtain the product, a white solid, yield 70.5%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3347-62-4, name is 3-Methyl-5-phenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 3347-62-4

General procedure: A mixture of (E)-4-phenylbut-3-en-2-one (1e) (146 mg, 1.0 mmol) and TsNHNH2 (205 mg, 1.1 mmol) in CH3CN (2 mL) were stirred at room temperature for 3 h and then CH3CN (2 mL), NaOH (44 mg, 1.1 mmol) were added and the mixture was heated at reflux for 17 h, then NaOH (60 mg, 1.5 mmol) and benzyl bromide (255 mg, 1.5 mmol) were subsequently added and the mixture was stirred at room temperature for 2 h. The product was extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. Purification by chromatography on silica gel afforded the desired product 4s as white crystalline solid (194 mg, 78% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 3469-69-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-69-0, name is 4-Iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 4-iodo-1H-pyrazole (7.00 g, 36.0 mmol) in 1,4-dioxane (30 mL) wasadded cyclopropylboronic acid (6.20 g, 72.0 mmol), cupric acetate monohydrate (9.40 g,47.0 mmol), 4-dimethylaminopyridine (108 mg, 43.0 mmol) and pyridine (3.50 g, 43.0 mmol) under nitrogen atmosphere. After stirred at 110 C overnight, the reaction mixture was cooled down to room temperature and diluted in water (50 mL), extracted with ethyl acetate (60 mL) for three times. The combined organic layers were washedwith brine (40 mL), dried over Na2 SO4() and filtered. The filtrate was concentrated under reduced pressure to give a crude product, which was purified by silica gel column chromatography (petroleum ether : ethyl acetate = 4 : 1) to afford the title compound (1.80 g, 21 % yield) as light yellow oil. ?HNMR (400 1VIHz, CDC13) 7.49 (s, 1H), 7.47 (s, 1H), 3.62- 3.57 (m, 1H), 1.13 – 1.08 (m, 2H), 1.05 – 0.99 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, SDS of cas: 35344-95-7

To a stirred solution of lH-pyrazole-4-carbaldehyde (S2-1) (200 mg, 2.08 mmol) in DMF (2 rnL) was added 2-iodopropane (707.66 mg, 4.16 mmol, 416.27 uL) and Cesium carbonate (1.36 g, 4.16 mmol) at ambient temperature. The resulting mixture was heated at 80C for 16 hours. It was then cooled to room temperature, diluted with ice cold w’ater and extracted with ethyl acetate. The combined extract was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The reaction mixture was purified by flash chromatography (eluting with 30% ethyl acetate-hexane) to afford l-isopropylpyrazoJe-4-carbaldehyde (S2-2) (200 mg, 1.45 mmol, 69.54% yield) as brown liquid. LCMS: ES+ 139.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.