Extracurricular laboratory: Synthetic route of 3469-69-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 3469-69-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-69-0, name is 4-Iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 4-iodo-1H-pyrazole (7.00 g, 36.0 mmol) in 1,4-dioxane (30 mL) wasadded cyclopropylboronic acid (6.20 g, 72.0 mmol), cupric acetate monohydrate (9.40 g,47.0 mmol), 4-dimethylaminopyridine (108 mg, 43.0 mmol) and pyridine (3.50 g, 43.0 mmol) under nitrogen atmosphere. After stirred at 110 C overnight, the reaction mixture was cooled down to room temperature and diluted in water (50 mL), extracted with ethyl acetate (60 mL) for three times. The combined organic layers were washedwith brine (40 mL), dried over Na2 SO4() and filtered. The filtrate was concentrated under reduced pressure to give a crude product, which was purified by silica gel column chromatography (petroleum ether : ethyl acetate = 4 : 1) to afford the title compound (1.80 g, 21 % yield) as light yellow oil. ?HNMR (400 1VIHz, CDC13) 7.49 (s, 1H), 7.47 (s, 1H), 3.62- 3.57 (m, 1H), 1.13 – 1.08 (m, 2H), 1.05 – 0.99 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.