Category: 139756-04-0

Adding a certain compound to certain chemical reactions, such as: 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 139756-04-0, Product Details of 139756-04-0

In step 1, 4-[2-propyloxy-5-(chlorosulfonyl)benzamido] – l-methyl-3-propyl-5-carbamoyl pyrazole is prepared. Precisely, the proper amount of 4-[2-propyloxy benzamido]-l-methyl-3-propyl-5-carbamoyl pyrazole is added to the solution of the proper amount of chlorosulfonic acid cooled at 0 0C. The mixture is stirred, filtered, washed and dried to give 4-[2-propyloxy-5-(chlorosulfonyl)benzamido ]- l-methyl-3-propyl-5-carbamoyl pyrazole.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, and friends who are interested can also refer to it.

Reference:
Patent; DONG-A PHARMACEUTICAL.CO., LTD.; WO2006/132460; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C18H24N4O3

Step 9 3-(5-Carbamoyl-1-methyl-3-propyl-1H-pyrazol-4-ylcarbamoyl)-4-propxy-benzenesulfonyl chloride: 2-Methyl-4-(2-propoxybenzoylamino)-5-propyl-2H-pyrazole-3-carboxamide (20 g, 58.1 mmol) was added to chlorosulfonic acid (81.3 g, 698 mmol) at 0 C. and the reaction was warmed to ambient temperature and stirred for 2 hours. The reaction mixture was poured into ice water (800 g) and mechanically stirred for 1 hour to give a white solid, which was filtered and washed with water. Following standard extractive work up, the solvent was evaporated under reduced pressure to yield the title compound (8 g, 31%). 1H NMR (300 MHz, CDCl3) delta 9.19 (s, 1H), 8.97 (s, 1H), 8.19 (t, 1H, J=8.9 Hz), 7.56 (br. s, 1H), 4.35 (t, 2H, J=6.6 Hz), 4.07 (s, 3H), 2.53 (t, 2H, J=7.5 Hz), 2.06-1.94 (m, 2H), 1.78-1.60 (m, 2H), 1.18 (t, 3H, J=7.5 Hz), 0.95 (t, 3H, J=7.2 Hz); LC-MS: m/z=443.1 (M+H)+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 139756-04-0.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2008/194529; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., Product Details of 139756-04-0

EXAMPLE 113 1-Methyl-5-(2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 1-Methyl-4-(2-n-propoxybenzamido)-3-n-propylpyrazole-5-carboxamide (0.34 g, 0.99 mmol) was added to a stirred mixture of 30% hydrogen peroxide solution (1.0 ml), potassium carbonate (0.54 g, 3.92 mmol), water (10 ml) and ethanol (5 ml). The mixture was heated under reflux for 38 hours and then evaporated under vacuum. The residue was suspended in water (20 ml), then the mixture acidified with 2N hydrochloric acid and extracted with dichloromethane (3*20 ml). The extracts are combined, dried (Na2SO4) and evaporated under vacuum. The resulting residue was chromatographed on silica gel (6 g), using a methanol in dichloromethane elution gradient (0.0-1.0%), to give an oil, successive trituration of which with ether gave the required product as a white solid (0.19 g, 59%), m.p. 111-114 C. Found: C, 66.26; H, 6.92; N, 17.15. C18H22N4O2 requires C, 66.23; H, 6.80; N, 17.17%.

The synthetic route of 139756-04-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cell Pathways, Inc.; US6200980; (2001); B1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 139756-04-0, Recommanded Product: 139756-04-0

3) 1-methyl-3-propyl-5 – (2-propoxy-phenyl) – 1,6-dihydro -7H-pyrazolo-[ 4,3-d] pyrimidin-7-one preparation: heating 6mmol compound 1-methyl-3-propyl-4 – (2-propoxy benzamido- ) pyrazole-5-carboxamide dissolved in 40 ml volume ratio (20-80): 1 ethanol in a mixture with hydrogen peroxide, add 6mmol naoh, stirring to dissolve, microwave heating 120 C reaction 25 minutes, after the reaction of the organic solvent is removed by reduced pressure distillation, the residue is distilled water washes, ethyl acetate extraction, organic subtraction-pressure distillation to remove the solvent, dried to obtain 1-methyl-3-propyl-5 – (2-propoxy-phenyl) – 1,6-dihydro -7H-pyrazolo-[ 4,3-d] pyrimidin-7-one, yield 85-90%;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Pharmaceutical University; CHEN, SIDONG; WANG, BAOGUO; MEI, WENJIE; ZHOU, JUNLI; JI, HENG; (20 pag.)CN103755709; (2016); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-04-0 as follows. Product Details of 139756-04-0

(Step a) Preparation of 4-[2-Propoxy-5-(Chlorosulfonyl)Benzamido]-1-Methyl-3-Propyl-5-Carbamoyl Pyrazole To 23 ml of chlorosulfonic acid cooled to 0 C., 10 g of 4-[2-propoxy benzamido]-1-methyl-3-propyl-5-carbamoyl pyrazole was added and then stirred at room temperature for 2 hours. Reaction mixture was added to ice water of 0 C. and then stirred for 1 hour to obtain white solid, which was filtered and washed with water. The obtained white solid was dissolved in ethyl acetate. The solution was successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain a crude product and triturated with hexane to give 9.14 g of the title compound. 1H NMR (CDCl3): 0.92(t,3H), 1.08(t,3H), 1.62(m,2H), 1.97(m,2H), 2.50(t, 2H), 4.04(s,3H), 4.32(t,2H), 5.63(br s,1H), 7.24(d,1H), 7.54(br s, 1H), 8.15(dd,1H), 8.93(d,1H), 9.17(br s,1H)

According to the analysis of related databases, 139756-04-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yoo, Moo-Hi; Kim, Won-Bae; Chang, Min-Sun; Kim, Soon-Hoe; Kim, Dong-Sung; Bae, Chul-Jun; Kim, Yong-Duck; Kim, Eun-Ha; US2003/176696; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 139756-04-0,Some common heterocyclic compound, 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, molecular formula is C18H24N4O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 19 1-Methyl-5-(2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 1-Methyl-4-(2-n-propoxybenzamido)-3-n-propylpyrazole-5-carboxamide (0.34 g, 0.99 mmol) was added to a stirred mixture of 30% hydrogen peroxide solution (1.0 ml), potassium carbonate (0.54 g, 3.92 mmol), water (10 ml) and ethanol (5 ml). The mixture was heated under reflux for 38 hours and then evaporated under vacuum. The residue was suspended in water (20 ml), then the mixture acidified with 2N hydrochloric acid and extracted with dichloromethane (3*20 ml). The extracts were combined, dried (Na2 SO4) and evaporated under vacuum. The resulting residue was chromatographed on silica gel (6 g), using a methanol in dichloromethane elution gradient (0.0-1.0%), to give an oil, successive trituration of which with ether gave the required product as a white solid (0.19 g, 59%), m.p. 111-114 C. Found: C,66.26; H,6.92; N,17.15. C18 H22 N4 O2 requires C,66.23; H,6.80; N,17.17%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5250534; (1993); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 139756-04-0, COA of Formula: C18H24N4O3

In step 1, 4-[2-propyloxy-5-(chlorosulfonyl)benzamido] – l-methyl-3-propyl-5-carbamoyl pyrazole is prepared. Precisely, the proper amount of 4-[2-propyloxy benzamido]-l-methyl-3-propyl-5-carbamoyl pyrazole is added to the solution of the proper amount of chlorosulfonic acid cooled at 0 0C. The mixture is stirred, filtered, washed and dried to give 4-[2-propyloxy-5-(chlorosulfonyl)benzamido ]- l-methyl-3-propyl-5-carbamoyl pyrazole.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide

(Step 1) Preparation of 4-[2-Propoxy-5-(Chlorosulfonyl)Benzamido]-1-Methyl-3-Propyl-5-Carbamoyl Pyrazole To 32.8 ml of chlorosulfonic acid cooled to 0 C., 8.48 ml of thionyl chloride and 20 g of 4-[2-propoxy benzamido]-1-methyl-3-propyl-5-carbamoyl pyrazole were successively added dropwise and portionwise, and then stirred for 2 hours at room temperature. Reaction mixture was added to ice water of 0 C. After 1 hour, the reaction mixture was extracted with ethyl acetate. The organic solution was successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain a crude product and triturated with a mixture of hexane:ethyl acetate (10:1) to give 23 g of the title compound. 1H NMR(CDCl3): 0.92(t,3H), 1.08(t,3H), 1.62(m,2H), 1.97(m,2H), 2.50(t, 2H), 4.04(s,3H), 4.32(t,2H), 5.63(br s,1H), 7.24(d,1H), 7.54(br s, 1H), 8.15(dd,1H), 8.93(d,1H), 9.17(br s,1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.