In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-04-0 as follows. Product Details of 139756-04-0
(Step a) Preparation of 4-[2-Propoxy-5-(Chlorosulfonyl)Benzamido]-1-Methyl-3-Propyl-5-Carbamoyl Pyrazole To 23 ml of chlorosulfonic acid cooled to 0 C., 10 g of 4-[2-propoxy benzamido]-1-methyl-3-propyl-5-carbamoyl pyrazole was added and then stirred at room temperature for 2 hours. Reaction mixture was added to ice water of 0 C. and then stirred for 1 hour to obtain white solid, which was filtered and washed with water. The obtained white solid was dissolved in ethyl acetate. The solution was successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain a crude product and triturated with hexane to give 9.14 g of the title compound. 1H NMR (CDCl3): 0.92(t,3H), 1.08(t,3H), 1.62(m,2H), 1.97(m,2H), 2.50(t, 2H), 4.04(s,3H), 4.32(t,2H), 5.63(br s,1H), 7.24(d,1H), 7.54(br s, 1H), 8.15(dd,1H), 8.93(d,1H), 9.17(br s,1H)
According to the analysis of related databases, 139756-04-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Yoo, Moo-Hi; Kim, Won-Bae; Chang, Min-Sun; Kim, Soon-Hoe; Kim, Dong-Sung; Bae, Chul-Jun; Kim, Yong-Duck; Kim, Eun-Ha; US2003/176696; (2003); A1;,
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