Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3920-40-9, name is 4-Amino-1-methyl-1H-pyrazole-3-carboxamide, A new synthetic method of this compound is introduced below., COA of Formula: C5H8N4O
Stage c A mixture of 2-(3-methanesulphonylphenyl)thiazole-4-carboxylic acid (120 mg) from stage b and 4-amino-1-methyl-1H-pyrazole-3-carboxamide (65 mg) in triethylamine (176 muL) and DMF (3 ml) in the presence of HATU (209 mg) is stirred at room temperature for 88 h. Water is added, the mixture is extracted with ethyl acetate and the organic phase is concentrated. Purification by preparative HPLC and purification by column chromatography on silica gel (mobile phase cyclohexane/acetone) result in 2-(3-methanesulphonylphenyl)thiazole-4-(3-carbamoyl-1-methyl-1H-pyrazol-4-yl)carboxamide (3.4 mg) as a white solid. C16H15N5O4S2, M=405.1; LC-MS (ZQ): Rt=0.92, m/z=406 [M+H]+. 1H-NMR (300 MHz, D6-DMSO): 3.31 (s, 3H), 3.90 (s, 3H), 7.56 (s, 1H), 7.72 (s, 1H), 7.84 (m, 1H), 8.07 (m, 1H), 8.32-8.38 (m, 2H), 8.43 (m, 1H), 8.55 (s, 1H), 11.3 (s, 1H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ulrich, BOTHE; Arne, Von Bonin; Duy, Nguyen; Ulf, Bomer; Judith, Guenther; US2009/163486; (2009); A1;,
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