Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 5-methyl-1H-pyrazole-3-carboxylate
Methyl 5-methylpyrazole-3-carboxylate (14 g, 0.1 mol), ethyl bromide (10.9 g, 0.1 mol),Tetrabutylammonium hydrogen sulfate (2.7 g, 0.008 mol), dissolved in 10 ml of dimethyl sulfoxide (DMSO),Potassium hydroxide solution was added dropwise [potassium hydroxide solution: a solution obtained by dissolving 22.4 g (0.40 mol) of potassium hydroxide in 20 ml of water],The reaction is exothermic, the addition is completed, and the mixture is stirred at room temperature overnight, diluted with water and quenched to adjust the pH to 2 to precipitate a white solid.Nuclear magnetic resonance test is a mixture of 1-ethyl-3-methylpyrazole-5-carboxylic acid and 1-ethyl-5-methylpyrazole-3-carboxylic acid.The ratio is 1:1, and the total weight of the product after drying is 14.6 g, and the yield is 94.8percent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.