Adding a certain compound to certain chemical reactions, such as: 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5071-61-4, Product Details of 5071-61-4
To a solution containing 0.31 g (1.65 mmol) of 5-phenyl-1H-pyrazole-3-carboxylic acid and 3 mL of DMF was added 0.77 g (1.82 mmol) of COMU, 0.28 g (1.73 mmol) of tert-butyl(3-aminopropyl)carbamate, and 0.45 mL (2.5 mmol) of DIPEA. The reaction mixture was allowed to stir at rt overnight, quenched by the addition of 10% HCl in water, and extracted with DCM. The combined organic layers were dried by passage through a phase separator cartridge and the solvent was removed under reduced pressure. The residue was subjected to silica gel chromatography to give 0.59 g (100%) of tert-butyl (3-(5-phenyl-1H-pyrazole-3-carboxamido)propyl)carbamate as a yellow oily solid. LC/MS ret. time=1.124 min, m/z=289.30 [M-C(CH3)3]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Phenyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Vanderbilt University; Lindsley, Craig W.; Waterson, Alex G.; Beauchamp, R. Daniel; (77 pag.)US2016/52896; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics