Reference of 5071-61-4,Some common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of intermediate 12-g (1.2 g, 2.30 mmol) in DMF, cooled to 0 C., were sequentially added 5-phenyl-1H-pyrazole-3-carboxylic acid (455 mg, 2.42 mmol), HATU (1.0 g, 2.77 mmol) and DIPEA (1.60 mL, 9.22 mmol) and the reaction mixture was stirred at 0 C. for 2 hours. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous ammonium chloride, saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 62-a as a white solid.
The synthetic route of 5071-61-4 has been constantly updated, and we look forward to future research findings.