Category: 92933-47-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Isopropyl-1H-pyrazole-3-carboxylic acid

Step 6 Example 1:(S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1-methyl-1H-pyrazol-4-yflpyridin-2-yl)pyrrolidin-1-yI)mcthanone Example 2:(R)-(34sopropyl-1H-pyrazol-5.yl)(3-(6-methyl-4-(1-methyl-1H-pyrazol-4-yi)pyridin-2-yl)pyrroiidin-1-yI)methanone Example 2:(R)-(34sopropyl-1H-pyrazol-5.yl)(3-(6-methyl-4-(1-methyl-1H-pyrazol-4-yi)pyridin-2-yl)pyrroiidin-1-yI)methanoneTo a stirred solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (133 mg, 0.86 mmol) in DMF (5 mL) was added DIPEA (372 mg, 2.88 mmol) and HATU (395 mg, 1.04 mmol) at room temperature. The mixture was stirred at room temperature for 10 mm, then 2-methyl-4-(1-methyl- lfJ-pyrazol-4-yl)-6-(pyrrolidin-3-yl)pyridine hydrochloride (200 mg, 0.72 mmol) was added and stirred at room temperature for 2 hrs. The mixture was diluted with EtOAc (200 mU, washed withbrine (90 mL x 3), dried over anhydrous Na2SO4, filtered, the filtrate was concentrated to give a residue which was purified by preparative TLC (DCM/ MeOH = 10: 1) to give a mixture of enantiomers (130 mg, 48% yield) as white solid, which was purified by chiral SFC to give two enantiomers Example 1 (with arbitrarily assigned stereochemistry) (44.7 mg, 16% yield) and Example 2 (with arbitrarily assigned stereochemistry) (34.5 mg, 13% yield).Example 1: ?H NMR (400 MHz, CDCI3) 6 7.84 (s, IH), 7,77 – 7.75 (m, 1H), 7.13 – 7.11 (m, 2H),6.50, 6.48 (2s, IH), 4.33 – 4.29 (m, 0.511), 4.22 – 4.14 (m, 1H), 4.03 – 4.92 (m, lH), 3.97 (s, 311),3.78 – 3.70 (m, 0.SH), 3.64 – 3.55 (m, lH), 3.07 – 3.01 (m, IH), 2.55 (s, 3H), 2.40 – 2.25 (m, 2H).1.33- 1.28 (m, 6H). LCMS (ESI) m/z: 378.9 [M+H1, RT 0.673 mm (LCMS method E). Example 2: 1H NMR (400 MHz, CDC13) b 7.84 (s, 111), 7.74 (s, 111), 7.12 – 7.11 (m, 1H), 7.10 (s,1H), 6.50, 6.48 (2s, 111), 4.33 – 4.29 (m, 0.511), 4.21 – 4.11 (m, 111), 4.07 – 3.90 (m, 2H), 4.01 (s,311), 3.78 – 3,71 (m, 0.511), 3.65 – 3.54 (m, IH), 3.09 – 3.00 (m, 111), 2.54 (s, 311), 2.46 – 2.28 (m,2H), 1.33 – 1.28 (m, 6H). LCMS (ESI) mlz: 379.0 [M+Hfb, RI = 0,673 mm (LCMS method E).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 92933-47-6.

Synthetic Route of 92933-47-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The aqueous solution of Eu(NO3)3.6H2O (1mmol) was treated with threefold excess of ethanolic solution of HIPA (3mmol) and the resulting mixture was thoroughly mixed on magnetic stirrer. The aqueous solution of NaOH was added drop wise to adjust the pH of mixture by 6-7. After constant stirring of 3 hr, off white precipitates of C1 binary complex were appeared which were isolated by vacuum filtration, washed with ethanol and water respectively, and then dried in desiccators.[19] Similarly, ternary complexes C2-C5 were synthesized by adding ethanolic solution of dmbipy, dipy, dmph and phen (1mmol) respectively, to the reaction mixture of europium(III) nitrate (1mmol) and ligand HIPA (3mmol) prior to adjustment of pH of the solution. Binary complex of gadolinium ion with ligand HIPA [Gd(IPA)3.2H2O] is synthesized by similar method as of C1 to calculate the triplet state of ligand. The synthetic routes of ligand HIPA and europium (III) complexes C1-C5 are shown in Fig. 1

The chemical industry reduces the impact on the environment during synthesis 5-Isopropyl-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate (7a)To a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (2.5 g, 16.2 mmol) [commercially available from Alfa Aesar, Ward Hill, MA, USA] in MeOH (25 mL) was added cone, sulfuric acid (1 mL) and refluxed for 12h. The reaction mixture was cooled and the solvent was removed under reduced pressure. The crude mass was purified by flash column chromatography using 1:9 MeOH in CHCl3 to yield compound 7a (2.6 g). 1H NMR (400 MHz, CDCl3): delta 6.64 (s, 1H), 4.39 (q, J=8.00 Hz, 2H), 3.06-3.01 (m, 1H), 1.39 (t, J=8.00 Hz, 3H), 1.31 (d, J=8.00 Hz, 6H). Molecular Formula: C9H14N2O2, LCMS purity: 96%; Expected: 182.1 ; Observed: 183 (M+1).

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Isopropyl-1H-pyrazole-3-carboxylic acid

General procedure: To a solution of HATU (174.17 mg, 0.459 mmol) and 3-isopropylpyrazole-5-carboxylic acid (59.85 mg, 0.388 mmol) in DMF (2 mL) was then added diisopropylethylamine (92 muL, 0.529 mmol). The reaction solution was stirred at room temperature for 2 h. The N-(3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)benzamide (100 mg, 0.353 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. After evaporation of the solvent and recrystallization from ethyl acetate, filtered and dried to give desired compound (50 mg, 34%).

According to the analysis of related databases, 92933-47-6, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Isopropyl-1H-pyrazole-3-carboxylic acid

Step 4 (R)-3-bromo-l-(1-(3-isopropyl-IH-pyrazole-5-earbonyl)pyrrolidin-3-yl)pyridin-2(lII)-onemixture of (R)-3-bromo-1-(pyrrolidin-3-yl)pyridin-2(1J])-one (3 g, 12.34 mmol), 3-isopropyl- 11-1-pyrazole-5-carboxylic acid (2.1 g, 13.58 mmol), HATU (5.6 g, 14.8 Immol) and DIEA (6.5837.02 mmol) in DMF (30 rnL) was stirred at room temperature for 12 hrs. The mixture wasdiluted with EtOAc (60 mL), washed with brine (60 mL x 2). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The crude residue was purified by preparative TLC (DCM: MeOH = 50: 1) to afford the desired product (1.6 g, 34% yield) as a light yellow solid. LCMS M/Z (M+Na) = 402.8.

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Related Products of 92933-47-6, These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3 N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)-3-metbyipyrrolidin-3-yJ)cyclopropanecarboxamideTo a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (431 mg, 2.79 mmol) in DMF (6 mL) were added HATU (1.38 g, 3.63 mmol) and DIEA (1.85 mL, 11.18 mmol) and then stirred at room temperature for 5 minutes before the addition of N-(3 -methylpyrrolidin-3-yl)cyclopropane carboxamide hydrochloride (572 mg, 2.79 mmol) was added. The resulting mixture was stirred at room temperature for 16 hrs. The reaction mixture was filtered and the crude product was purifiedby preparative HPLC (Gemini C18, 150 x 25 mm xlO jam, 26-56% MeCN/H20) to give the desiredproduct (210 mg, 25% yield) as white solid. ?H NMR (400 MHz, DMSO-d6) 6 8.09 (s, IH), 6.41(s, IH), 4.17 – 4.14 (m, 0.SH), 3.88-3.72 (m, 2H), 3.55 -3.52 (m, 1H), 3.38 – 3.35 (m, 0.SH), 2,96-2.93 (m, IH), 2,31 -2.19 (m, 1H), 1.88- 1.72 (m, IH), 1.56- 1.53 (m, 111), 1.38 (s, 3H), 1.22(d, J 7.2 Hz, 6H), 0.63 -0.57 (m, 4H). LCMS (ESI) mlz: 305,1 [M+HJ, RT 0.904 mm(LCMS Method E).

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of HATU (174.17 mg, 0.459 mmol) and 3-isopropylpyrazole-5-carboxylic acid (59.85 mg, 0.388 mmol) in DMF (2 mL) was then added diisopropylethylamine (92 muL, 0.529 mmol). The reaction solution was stirred at room temperature for 2 h. The N-(3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)benzamide (100 mg, 0.353 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. After evaporation of the solvent and recrystallization from ethyl acetate, filtered and dried to give desired compound (50 mg, 34%). 1H NMR (300 MHz, DMSO-d6) ppm 13.00 (s, 1H), 11.93 (s, 1H), 7.98 (d, J = 7.40 Hz, 2H), 7.67 (t, J = 7.15 Hz, 1H), 7.59 (t, J = 7.47 Hz, 2H), 6.40 (s, 1H), 5.18 (br. s., 0.9H), 4.75 (br. s., 1.1H), 4.20 (br. s., 1.2H), 3.93 (br. s., 0.8H), 2,91-3.10 (m, 1H), 2.78 (br. s., 2H), 1.25 (d, J = 5.7 Hz, 6H). 13C NMR (101 MHz, DMSO-d6) ppm 166.7, 164.5, 146.7, 147.0, 139.5, 139.2, 133.3, 132.7, 131.0, 128.8, 125.9, 114.3, 104.1, 95.6, 44.0, 41.5, 25.6, 25.4 22.7. LC/MS (ESI+, MeCN/H2O): m/z: calcd for C22H21N5O2S: 419.14 [M+H]+; found: 420.1.

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Reference of 92933-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The aqueous solution of Eu(NO3)3.6H2O (1mmol) was treated with threefold excess of ethanolic solution of HIPA (3mmol) and the resulting mixture was thoroughly mixed on magnetic stirrer. The aqueous solution of NaOH was added drop wise to adjust the pH of mixture by 6-7. After constant stirring of 3 hr, off white precipitates of C1 binary complex were appeared which were isolated by vacuum filtration, washed with ethanol and water respectively, and then dried in desiccators.[19] Similarly, ternary complexes C2-C5 were synthesized by adding ethanolic solution of dmbipy, dipy, dmph and phen (1mmol) respectively, to the reaction mixture of europium(III) nitrate (1mmol) and ligand HIPA (3mmol) prior to adjustment of pH of the solution. Binary complex of gadolinium ion with ligand HIPA [Gd(IPA)3.2H2O] is synthesized by similar method as of C1 to calculate the triplet state of ligand. The synthetic routes of ligand HIPA and europium (III) complexes C1-C5 are shown in Fig. 1

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 92933-47-6

General procedure: To a solution of HATU (104 mg, 0.27 mmol) and 3-isopropylpyrazole-5-carboxylic acid (36 mg, 0.22 mmol) in DMF (14 mL) was then added diisopropylethylamine (0.055 mL, 0.31 mmol). The reaction solution was stirred at room temperature for 2 h. 2-(Benzylamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (75 mg, 0.21 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. The resulting residue was purified by column chromatography on silica gel (EtOAc/hexane = 2:1) to give title compound as a white solid (33 mg, 37%).

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H10N2O2

Example 1. Synthesis of 5-(propan-2-yl)-N-{4-[(pyrimidin-2- yl)sulfamoyl]phenyl}-lH-pyrazole-3-carboxamide, 1-17 1-17 [00265] HATU (460mg, 1.2 mmol) and DIPEA (0.42 ml, 2.4 mmol) were added at Rt to a stirred solution of 3-(propan-2-yl)-lH-pyrazole-5-carboxylic acid (120mg, 0.8 mmol) in DMF (HPLC grade, 7 ml) followed by 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (200mg, 0.8 mmol). The resulting mixture was stirred at Rt for 20h. The solvent was removed in vacuo and the remaining material was purified by prep HPLC (MeCN/Water, 0.1% formic acid) to afford lOmg (3%) of 5-(propan-2-yl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}-lH-pyrazole-3- carboxamide 1-17 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 13.15 (s, 1H), 10.29 (s, 1H), 8.48 (d, J = 4.8 Hz, 2H), 7.98 (d, J = 8.6 Hz, 2H), 7.91 (d, J = 8.6 Hz, 2H), 7.01 (s, 1H), 6.54 (s, 1H), 3.11 – 2.77 (m, 1H), 1.25 (d, J = 6.9 Hz, 6H).

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.